Anti-CASP3 Recombinant Antibody Products

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Anti-CASP3 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs, a world-class provider of reagents for apoptosis and cancer research, is your one-stop-shop for top-tier, recombinant anti-CASP3 antibodies. Caspase-3 (CASP3) is the major executioner caspase of the apoptotic cell death pathway, and our high-quality antibodies are essential tools to detect apoptosis, screen anti-cancer compounds for efficacy, and dissect the machinery of cell death.

CASP3: The Central Executioner of Apoptosis

Caspase-3 is a cysteine protease and, by many measures, the most important of the executioner caspases. Caspase-3 is synthesized as an inactive zymogen called pro-caspase-3 and is found at significant levels in nearly all cells. In cells undergoing apoptosis, it is activated by cleavage at specific sites by initiator caspases (for example, caspase-8 or caspase-9). Cleaved and active caspase-3 then goes on a proteolytic rampage, cleaving hundreds of cellular protein substrates. The resulting loss of protein integrity and function manifests as the classic morphological and biochemical changes of apoptosis, including DNA fragmentation (cleavage of the inhibitor of caspase-activated DNase), membrane blebbing, and orderly cellular dismantling.

Alternative Names

Caspase 3; Caspase 3, Apoptosis-Related Cysteine Peptidase; Caspase 3, Apoptosis-Related Cysteine Protease; SREBP Cleavage Activity 1; Cysteine Protease CPP32; Protein Yama; EC 3.4.22.56; Apopain; CASP-3

Background

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

Anti-CASP3 rAb Products

Creative Biolabs' anti-CASP3 recombinant antibodies are the gold standard for apoptosis research. We have antibodies that detect the full-length pro-form of caspase-3 as well as, more importantly, antibodies that are highly specific for the cleaved, active form of caspase-3. Cleavage-specific antibodies are the most reliable means to detect and quantify apoptotic cells by Western Blot, IHC, and immunofluorescence.

Table 1. Featured anti-CASP3 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Quality and customer service are at the heart of everything we do at Creative Biolabs. Our proprietary and state-of-the-art manufacturing facility produces all of our recombinant antibodies in accordance with a strict quality assurance system. Every lot is thoroughly tested for purity and specificity, and – especially in the case of our cleavage-specific antibodies – repeatedly validated for consistent performance in well-established models of apoptosis induction.

Customer Reviews

Excellent

A**ie
Mouse Anti-CASP3 Recombinant Antibody (clone 5E1)

The cleaved Caspase-3 antibody from Creative Biolabs is the best apoptosis marker, period. The IHC staining on our tumor sections after chemotherapy is super clean and really specific for dying cells.

2/Feb/2023

Excellent

C**lo
Rabbit Anti-CASP3 Recombinant Antibody (clone 2B10)

We use the cleaved CASP3 antibody for all of our apoptosis assays via Western blot. The presence of the cleaved band is an unambiguous, quantifiable readout of cell death. Essential.

11/Mar/2024

rAb Production

Creative Biolabs employs state-of-the-art production technologies to help drive progress in the field of cell death research. Our anti-cleaved CASP3 recombinant antibodies are carefully engineered and screened to ensure that they only recognize the activated form of the enzyme.

Featured Anti-CASP3 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CASP3 recombinant antibody production.

Fig.4 Gram-scale anti-CASP3 recombinant antibody production.

rAb Modalities

Creative Biolabs' goal is to provide flexible and innovative tools that meet the needs of our research community. Our anti-CASP3 antibodies are available in a variety of formats and conjugations for many applications and platforms including flow cytometry and high-content imaging.

Fig.5 Full-length anti-CASP3 recombinant antibody production and modalities.

Drive progress in apoptosis research with Creative Biolabs' superior anti-CASP3 recombinant antibodies. Defined by its unparalleled specificity and rigorous validation, our portfolio of cleavage-specific antibodies is the ideal tool for cancer drug discovery and fundamental cell death studies. Trust our expertise to support your important work. Speak to our specialists today.

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