Anti-Human CCR6 Recombinant Antibody (MSM-R605)
CAT#: TAB-1543CL
This fully human antibody against human CCR6 can be used to detect the presence of CCR6 on cells, so it also can be used to decrease the effects of over-stimulation of CCR6 in a variety of conditions and disorders, including cancers.
Published Data
Gene Expression
FC
Figure 1 A graph of fluorescence of CHO cells expressing human CCR6, cynoCCR6, mouse CCR6 and CHO host cells in the presence of varying concentration of IgG1 antibodies MSM-R605 and labeled with a commercial anti-human Fc PE-conjugate.
Figure 2 A graph of inhibition of the increase in the intracellular Ca concentration in response to addition of human CCL20 to Chem-1 cells expressing human CCR6 in the presence of inhibiting IgG1 antibodies MSM-R605 at varying concentration.
FC
Figure 3 Graphs of MFI of cells exposed to IgG antibodies (MSM R605).
FIG. A depicts human PBMCs, FIG. B depicts Cynomologus monkey PBMCx, and FIG. C depicts mouse splenocytes.
Figure 4 Graphs of binding of an antibody against CCR6 (MSM R605) to human PBMCs, cynomologus monkey PBMCs, and mouse splenocytes.
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Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_8_5.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6820/17235_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (Hep G2, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000112486-CCR6
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Specifications
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Species Reactivity
- Cyno CCR6
- Clone
- MSM-R605
- Applications
- FC
- Related Disease
- Cancers
Applications
- Application Notes
- This antibody has been tested for use in Flow Cytometry.
Target
- Alternative Names
- CCR6; chemokine (C-C motif) receptor 6; BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6; C-C chemokine receptor type 6; LARC receptor; chemokine receptor-like 3; chemokine (C-C) receptor 6; G protein-coupled receptor 29; G-protein coupled receptor 29; seven-transmembrane receptor, lymphocyte, 22
- Gene ID
- 1235
- UniProt ID
- P51684
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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- CAT
- Product Name
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