This immunotoxin was achieved by conjugating/fusing the Anti-CCR9 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CCR9 expression cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-162 | Recombinant Anti-human CCR9 Antibody | WB, Neut, FuncS | IgG |
MHH-162 | Recombinant Human Anti-human CCR9 Antibody | WB, IF, FuncS | IgG |
MOB-0376CT | Mouse Anti-CCR9 Recombinant Antibody (clone DX-2.3) | FC | Mouse IgG2a |
ZG-0583J | Rabbit Anti-CCR9 Recombinant Antibody (clone 4G2) | ELISA, WB, IF, IP | Rabbit IgG |
VS1-YJ23 | Rat Anti-CCR9 Recombinant Antibody (clone 7E7) | IF, IHC-Fr, FC | Rat IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-162-F(E) | Recombinant Anti-human CCR9 Antibody Fab Fragment | RIA, ELISA, FuncS | Fab |
MHH-162-F(E) | Recombinant Human Anti-human CCR9 Antibody Fab Fragment | FC, IP, FuncS | Fab |
HPAB-0039-LS-S(P) | Mouse Anti-CCR9 Recombinant Antibody; scFv Fragment (HPAB-0039-LS-S(P)) | FC, WB, ELISA | Mouse scFv |
HPAB-0040-LS-S(P) | Mouse Anti-CCR9 Recombinant Antibody; scFv Fragment (HPAB-0040-LS-S(P)) | FC, WB, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-162-S(P) | Recombinant Anti-human CCR9 Antibody scFv Fragment | FC, WB, FuncS | scFv |
MHH-162-S(P) | Recombinant Human Anti-human CCR9 Antibody scFv Fragment | IF, Neut, FuncS | scFv |
HPAB-0039-LS-F(E) | Mouse Anti-CCR9 Recombinant Antibody; Fab Fragment (HPAB-0039-LS-F(E)) | FC, WB, ELISA | Mouse Fab |
HPAB-0040-LS-F(E) | Mouse Anti-CCR9 Recombinant Antibody; Fab Fragment (HPAB-0040-LS-F(E)) | FC, WB, ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0525 | Hi-Affi™ Rabbit Anti-CCR9 Recombinant Antibody (clone DS525AB) | WB, ICC, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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