Anti-CCR9 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs supports your gastroenterology and immunology research with ultra-specific anti-CCR9 recombinant antibodies. CCR9 is the chemokine receptor uniquely responsible for T-cell trafficking to the gut. It is therefore a critical factor in intestinal immunity and the pathophysiology of Inflammatory Bowel Disease (IBD). Creative Biolabs’ high-quality antibodies are the ideal reagents to study gut-homing lymphocytes and to enable you to develop therapies to selectively target Crohn’s disease and ulcerative colitis.

CCR9: The Gut-Homing Chemokine Receptor

C-C Motif Chemokine Receptor 9 (CCR9) is a G-protein coupled receptor that is selectively expressed by a subset of T-lymphocytes. It has a single ligand, the chemokine CCL25 (TECK), which is constitutively produced by epithelial cells lining the small intestine. The interaction between CCR9 and its ligand CCL25 serves as a powerful homing signal, guiding CCR9-expressing T-cells from the bloodstream into the lamina propria and epithelium of the intestine. In Inflammatory Bowel Disease (IBD), CCR9 and CCL25 play a central role in driving the influx of pathogenic T-cells that leads to chronic intestinal inflammation and tissue damage.

Alternative Names

GPR28; CDw199; GPR-9-6; CC-CKR-9; C-C chemokine receptor type 9; G protein-coupled receptor 28; chemokine (C-C motif) receptor 9

Background

CCR9 (C-C Motif Chemokine Receptor 9) is a Protein Coding gene. Diseases associated with CCR9 include Celiac Disease 1 and Cd45 Deficiency. Among its related pathways are Akt Signaling and Allograft rejection. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR7.

Anti-CCR9 rAb Products

Creative Biolabs’ recombinant anti-CCR9 antibodies are engineered to provide the highest specificity and performance. These antibodies have been thoroughly validated to reliably detect the CCR9 receptor on the surface of gut-homing T-cells. Optimized for multiple applications, including multi-color flow cytometry to identify these specialized lymphocytes or functional blocking to inhibit CCL25-mediated chemotaxis, our recombinant antibodies (rAbs) offer the consistent performance needed to dissect IBD pathophysiology.

Table 1. Featured anti-CCR9 recombinant antibody products at Creative Biolabs.

Creative Quality Control

We are scientists too. That is why we don’t cut corners at Creative Biolabs. The manufacture of Creative Biolabs’ anti-CCR9 recombinant antibodies is supported by a rigorous quality control program. All lots are extensively validated for purity and specificity as well as robust performance in flow cytometry and functional applications.

Customer Reviews

rAb Production

Creative Biolabs leverages leading-edge antibody production platforms to serve the specialized field of gastroenterology. Our recombinant anti-CCR9 antibodies are expressed in systems optimized to ensure correct recognition of the native receptor. This results in a highly specific and active reagent for your research applications.

Featured Anti-CCR9 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-CCR9 recombinant antibody production.

Fig.4 Gram-scale anti-CCR9 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to advancing scientific research by providing flexible antibody solutions. Our anti-CCR9 recombinant antibodies are available in a range of formats, including functional blocking clones, to meet the needs of your experiments and empower researchers everywhere to study this important receptor.

Fig.5 Full-length anti-CCR9 recombinant antibody production and modalities.

CCR9-Targeted Drug Information

Table 2. Public drug targeting CCR9.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Probe the mechanisms of intestinal inflammation using Creative Biolabs’ recombinant anti-CCR9 antibodies. Our suite of antibodies is stringently validated and backed by the performance consistenc