Afuco™ Anti-Human CD55 ADCC Recombinant Antibody (PAT-SC1), ADCC Enhanced (CAT#: AFC-126CL)
Anti-CD55 ADCC Enhanced Antibody (PAT-SC1) is an ADCC enhanced antibody produced by our Afuco™ platform. PAT-SC1 has a strong potential to be used as an additive therapeutic agent in the treatment of patients with gastric cancers. A study conducted between 1997 and 2001, a single 20mg dose of PAT-SC1 administered before gastric resection surgery induced cell killing in human primary gastric tumours. This led to tumour cell regression in over half of PAT-SC1-treated patients. In the 10 year follow-up study of patients that participated in the trial, survival is significantly higher for PAT-SC1 treated patients as compared to an historical control group of patients that underwent a gastric resection but were not treated with PAT-SC1.
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Figure 1 Ten-year overall survival rates of the R0-resected patients as assessed by Kaplan-Meier analysis.
Kaplan-Meier-curve of R0-resected,CD55PAT-SC1-expressing gastric cancer patients (dashed line) vs.R0-resected gastric cancer patients which did not express CD55 PAT-SC1 (black line). Gastric cancer patients that did not express CD55PAT-SC1 tended to have a prolonged rate when compared to those expressing CD55PAT-SC1 (p=0.237).
Hensel, F.,Timmermann,W.,Von Rahden, B. H.,Rosenwald, A., Brändlein, S.,&Illert, B.(2014).Ten-year follow-up of a prospective trial for the targeted therapy of gastric cancer with the human monoclonal antibody PAT-SC1.Oncology reports, 31(3),1059-1066.
Figure 2 Analysis of the apoptotic activity of the PAT-SC1 antibody in vivo.
(A and B) A pre-treatment biopsy and (C and D)a post-treatment tumour sample of a stomach carcinoma patient were investigated for PAT-SC1-induced apoptosis using the Klenow FragEL DNA fragmentation kit (Oncogene,Boston, MA, USA).(A and C) In the positive controls,all cell nuclei are stained due to treatment with an endonuclease.(B and D) In the images (right panels) only the nuclei of apoptotic stomach tumour cells are stained.(B)The pre-treatment biopsy shows no apoptotic activity.(D)In the post-treatment tumour sample an increase in apoptotic tumour cells after PAT-SC1 treatment is noted.
Hensel, F.,Timmermann,W.,Von Rahden, B. H.,Rosenwald, A., Brändlein, S.,&Illert, B.(2014).Ten-year follow-up of a prospective trial for the targeted therapy of gastric cancer with the human monoclonal antibody PAT-SC1.Oncology reports, 31(3),1059-1066.
Figure 3 Ten-year overall survival rates of the R0-resected patients with or without PAT-SC1 antibody treatment as assessed by Kaplan-Meier analysis.
Kaplan-Meier curves of R0-resected, CD55PAT-SC1-expressing gastric cancer patients following PAT-SC1 treatment (black line) vs. R0-resected. CD55PAT-SC1-expressing untreated gastric cancer patients (dashed line). PAT-SC1-treated patients tended to have a survival benefit when compared to the untreated patients (p=0.219).
Hensel, F.,Timmermann,W.,Von Rahden, B. H.,Rosenwald, A., Brändlein, S.,&Illert, B.(2014).Ten-year follow-up of a prospective trial for the targeted therapy of gastric cancer with the human monoclonal antibody PAT-SC1.Oncology reports, 31(3),1059-1066.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- Purity>95% by SDS-PAGE
- Storage
- 4 °C, -20°C if preferred
Target
- Alternative Names
- CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group); CR; TC; DAF; CROM; complement decay-accelerating factor; CD55 antigen
- Gene ID
- 1604
- UniProt ID
- P08174
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-316LC | Human Anti-CD55 Recombinant Antibody (TAB-316LC) | ELISA, FC, Inhib | Human IgG1 |
| TAB-316LC-S(P) | Human Anti-CD55 Recombinant Antibody; scFv Fragment (TAB-316LC-S(P)) | ELISA | Human scFv |
| TAB-316LC-F(E) | Human Anti-CD55 Recombinant Antibody; Fab Fragment (TAB-316LC-F(E)) | ELISA | Human Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0102MZ | Chicken Anti-CD55 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-393CQ | Mouse Anti-CD55 Recombinant Antibody (clone CBL021) | Neut, WB | Mouse IgG2 |
| NEUT-394CQ | Mouse Anti-CD55 Recombinant Antibody (clone MM0175-12L29) | IHC-P, WB, Neut | Mouse IgG2 |
| NEUT-395CQ | Mouse Anti-CD55 Recombinant Antibody (clone CBL739) | WB, Neut | Mouse IgG2b |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0570 | Hi-Affi™ Rabbit Anti-CD55 Recombinant Antibody (clone DS570AB) | WB, IHC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0498-CN-S(P) | Mouse Anti-CD55 Recombinant Antibody; scFv Fragment (HPAB-0498-CN-S(P)) | ELISA, FC, Neut | Mouse scFv |
| HPAB-0054-YJ-S(P) | Human Anti-CD55 Recombinant Antibody (clone LU30); scFv Fragment | FC, ELISA, IHC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0498-CN-F(E) | Mouse Anti-CD55 Recombinant Antibody; Fab Fragment (HPAB-0498-CN-F(E)) | ELISA, FC, Neut | Mouse Fab |
| HPAB-0054-YJ-F(E) | Human Anti-CD55 Recombinant Antibody (clone LU30); Fab Fragment | FC, ELISA, IHC | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1755-CN | Rabbit Anti-CD55 Polyclonal Antibody (MRO-1755-CN) | WB, IF, IHC | Rabbit IgG |
| ZG-0592J | Rabbit Anti-CD55 Recombinant Antibody (clone 1A5) | ELISA, WB, IHC | Rabbit IgG |
| VS2-QX14 | Mouse Anti-CD55 Recombinant Antibody (clone BRIC 110) | IHC, WB | Mouse IgG1, κ |
| VS2-QX15 | Mouse Anti-CD55 Recombinant Antibody (clone BRIC 128) | IHC, WB | Mouse IgM, κ |
| VS2-QX16 | Mouse Anti-CD55 Recombinant Antibody (clone BRIC 216) | IHC, WB | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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