Mouse Anti-CEA Recombinant Antibody (clone MFE-23) (CAT#: PABL-037)

Recombinant Mouse Antibody (MFE-23) is capable of binding to CEA, expressed in Chinese Hamster Ovary cells (CHO).

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FC

Figure 1 Characterization of scFv'-fragments targeting EGFR- or CEA-expressing tumor cells.

Figure 1 Characterization of scFv'-fragments targeting EGFR- or CEA-expressing tumor cells.

Flow cytometry analysis of binding of the two scFv fragments to A549 cells.

Mack, K., Rüger, R., Fellermeier, S., Seifert, O., & Kontermann, R. E. (2012). Dual targeting of tumor cells with bispecific single-chain Fv-immunoliposomes. Antibodies, 1(2), 199-214.

ELISA

Figure 2 ELISA analyzing the binding of monospecific ILs (hu225-IL, MFE23-IL), dual-targeted immunoliposomes (dt-ILs) as well as non-targeted liposomes (nt) to immobilized CEA and detection of bound liposomes by incubation with EGFR-Fc and an anti-Fc antibody.

Figure 2 ELISA analyzing the binding of monospecific ILs (hu225-IL, MFE23-IL), dual-targeted immunoliposomes (dt-ILs) as well as non-targeted liposomes (nt) to immobilized CEA and detection of bound liposomes by incubation with EGFR-Fc and an anti-Fc antibody.

Only the dt-ILs caused a signal confirming bispecificity.

Mack, K., Rüger, R., Fellermeier, S., Seifert, O., & Kontermann, R. E. (2012). Dual targeting of tumor cells with bispecific single-chain Fv-immunoliposomes. Antibodies, 1(2), 199-214.


Specifications

  • Immunogen
  • Human Carcinoembryonic Antigen
  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Human CEA
  • Species Reactivity
  • Human
  • Clone
  • MFE-23
  • Applications
  • ELISA, WB, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Flow Cytometry and Enzyme-Linked Immunosorbent Assay.

Target

  • Alternative Names
  • CEA; Carcinoembryonic Antigen

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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