Recombinant Mouse Antibody (MFE-23) is capable of binding to CEA, expressed in Chinese Hamster Ovary cells (CHO).
Figure 1 Characterization of scFv'-fragments targeting EGFR- or CEA-expressing tumor cells.
Flow cytometry analysis of binding of the two scFv fragments to A549 cells.
Mack, K., Rüger, R., Fellermeier, S., Seifert, O., & Kontermann, R. E. (2012). Dual targeting of tumor cells with bispecific single-chain Fv-immunoliposomes. Antibodies, 1(2), 199-214.
Figure 2 ELISA analyzing the binding of monospecific ILs (hu225-IL, MFE23-IL), dual-targeted immunoliposomes (dt-ILs) as well as non-targeted liposomes (nt) to immobilized CEA and detection of bound liposomes by incubation with EGFR-Fc and an anti-Fc antibody.
Only the dt-ILs caused a signal confirming bispecificity.
Mack, K., Rüger, R., Fellermeier, S., Seifert, O., & Kontermann, R. E. (2012). Dual targeting of tumor cells with bispecific single-chain Fv-immunoliposomes. Antibodies, 1(2), 199-214.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0059-YC-S(P) | Mouse Anti-CEA Recombinant Antibody (clone 2-18); scFv Fragment | IF, FuncS | Mouse scFv |
FAMAB-0060-YC-S(P) | Mouse Anti-CEA Recombinant Antibody (clone ch2-18); scFv Fragment | IF, FuncS | Mouse scFv |
FAMAB-0061-YC-S(P) | Mouse Anti-CEA Recombinant Antibody (clone Fll-35); scFv Fragment | IP, FuncS | Mouse scFv |
FAMAB-0062-YC-S(P) | Mouse Anti-CEA Recombinant Antibody (clone Fl1-39); scFv Fragment | IP, FuncS | Mouse scFv |
FAMAB-0083JF-S(P) | Mouse Anti-CEA Recombinant Antibody (clone C1); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# PABL-037, RRID: AB_3111622)
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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