Mouse Anti-CTSB Recombinant Antibody (clone 2A2); Fab Fragment (CAT#: NS-015CN-F(E))
Recombinant monoclonal antibody to cathepsin B. 2A2 is a mouse antibody that can be used for the detection or treatment of diseases associated with an over-expression and/or excessive activity of cathepsin B, such as cancer or arthritis.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoli, the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18156/150_G3_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoli, the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18156/150_G3_2_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/457/613_B10_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/457/613_B10_3_selected.jpg
Figure 3 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows cytoplasmic positivity in glandular cells. Brunner's glands were also positive while Paneth cells were negative.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18156/41696_A_8_2_selected.jpg
(Immunohistochemical staining of human duodenum shows cytoplasmic positivity in glandular cells. Brunner's glands were also positive while Paneth cells were negative.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18156/41696_A_8_2_selected.jpg
Figure 4 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_A_9_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_A_9_4.jpg
Figure 5 Cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_B_9_5.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_B_9_5.jpg
Figure 6 Thyroid gland
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_B_1_5.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_B_1_5.jpg
Figure 7 Colon
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_A_7_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48998/167916_A_7_3.jpg
Figure 8 RNA cell line category: Cell line enhanced (BJ hTERT+, fHDF/TERT166)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164733-CTSB
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164733-CTSB
Specifications
- Immunogen
- Highly purified recombinant human cathepsin B
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human CTSB
- Species Reactivity
- Human
- Clone
- 2A2
- Applications
- ELISA, WB
- Related Disease
- Cancer or arthritis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Cathepsin B; APP Secretase; Cathepsin B1; EC 3.4.22.1; APPS; CPSB; Amyloid Precursor Protein Secretase; Cysteine Protease; EC 3.4.22
- Gene ID
- 1508
- UniProt ID
- P07858
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1862z | Mouse Anti-CTSB Recombinant Antibody (clone 41C6) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0334CT | Recombinant Mouse anti-Human CTSB Monoclonal antibody (DC242) | IHC-P | |
| MRO-1724-CN | Rabbit Anti-CTSB Polyclonal Antibody (MRO-1724-CN) | WB, IF | Rabbit IgG |
| MOB-284YJL | Rabbit Anti-CTSB Recombinant Antibody (clone CBC269) | ELISA | Rabbit IgG |
| VS3-WK1393 | Rabbit Anti-CTSB Recombinant Antibody (VS3-WK1393) | WB, ELISA | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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