Anti-CTSB Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a global frontrunner in providing top-of-the-class research tools for both oncology and lysosomal biology. Among many of our leading antibodies, our elite anti-CTSB recombinant antibodies are of great interest to the research community. As a potent lysosomal cysteine protease, Cathepsin B (CTSB) is commonly mis-trafficked in cancer and heavily implicated in tumor invasion and metastasis. Our high-quality antibodies are essential for probing cancer progression, lysosomal storage disorders, and developing new anti-cancer therapeutics.

CTSB: A Lysosomal Protease in Cancer Invasion

Cathepsin B (CTSB) is a lysosomal cysteine protease with a crucial role in intracellular protein turnover. Normally, it is strictly confined to the lysosome. In many cancers, however, its expression is induced, and it is mis-trafficked to the cell surface or secreted to the extracellular space. In this ectopic location, Cathepsin B exhibits its robust proteolytic activity on components of the extracellular matrix (ECM) and basement membrane to facilitate tumor cell dissociation from the primary site, invade surrounding tissues and metastasize to secondary locations.

Alternative Names

CTSB; EC 3.4.22.1; Amyloid Precursor Protein Secretase; Cysteine Protease; EC 3.4.22; CPSB; Cathepsin B

Background

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified.

Anti-CTSB rAb Products

Creative’s anti-CTSB recombinant antibodies have been engineered to provide superior specificity and performance. They are extensively validated to detect the pro-, single-chain, and heavy-chain form of the enzyme. Optimized for applications including Western Blot, IHC to study its tumor-specific localization, and as a tool for activity assays, our rAbs are state-of-the-art tools for cancer biology research.

Table 1. Featured anti-CTSB recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is at the forefront of research progress in cancer with our latest production technologies. Our anti-CTSB recombinant antibodies are expertly developed to provide the highest specificity and sensitivity possible to detect this major driver of metastasis.

Featured Anti-CTSB Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CTSB recombinant antibody production.

Fig.2 Gram-scale anti-CTSB recombinant antibody production.

rAb Modalities

Creative Biolabs is all about supporting innovation with flexibility in the research community. Our anti-CTSB antibodies are available in a variety of modalities that are optimized for developing activity-based probes or in vivo imaging.

Fig.3 Full-length anti-CTSB recombinant antibody production and modalities.

Power your research into cancer invasion with Creative Biolabs’ superior anti-CTSB recombinant antibodies. Our product portfolio is defined by its unrivaled specificity and extensive validation, making the ideal tools for drug discovery and basic cancer biology research. Trust our team of experts to support your important work. Reach out to our specialists today.