Afuco™ Anti-Human CXCL8 ADCC Recombinant Antibody (ABX-IL8), ADCC Enhanced
CAT#: AFC-191CL
Anti-CXCL8 ADCC Enhanced Antibody (ABX-IL8) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a human IgG2 monoclonal antibody directed against human IL-8, which should be considered as a treatment modality for other solid tumors in which IL-8 plays an angiogenic role, including bladder, prostate, ovarian and lung cancers. ABX-IL8 was shown to be safe and well tolerated in both the single-dose and the multiple dose trials. No serious or unexpected adverse events have been reported, no immunogenicity has been detected, and there has been no evidence of cytokine release syndrome in either of the trials.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/1010_F11_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows moderate cytoplasmic positivity in non germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line GAMG
Immunofluorescent staining of human cell line GAMG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/2058_E8_1_blue_red_green.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_8_8.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169429-CXCL8
❮
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Chronic Bronchitis; Chronic obstructive pulmonary disease; Inflammatory Diseases; Melanoma; Psoriasis; Rheumatoid Arthritis
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Target
- Alternative Names
- CXCL8; chemokine (C-X-C motif) ligand 8; IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; interleukin-8; emoctakin; interleukin 8; T-cell chemotactic factor; neutrophil-activating peptide 1; beta-thromboglobulin-like protein; granulocyte chemotactic protein 1; tumor necrosis factor-induced gene 1; alveolar macrophage chemotactic factor I; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; small inducible cytokine subfamily B, member 8; lymphocyte derived neutrophil activating peptide; lung giant cell carcinoma-derived chemotactic protein; beta endothelial cell-derived neutrophil activating peptide
- Gene ID
- 3576
- UniProt ID
- A0A024RDA5
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1166z | Mouse Anti-CXCL8 Recombinant Antibody (clone 19C12) | WB, ELISA, FC, ICC, IHC, Neut | Mouse IgG1 |
| HPAB-N0059-YC | Human Anti-CXCL8 Recombinant Antibody (HPAB-N0059-YC) | FuncS | Human IgG |
| HPAB-1501-FY | Mouse Anti-CXCL8 Recombinant Antibody (clone 5D2.2D10) | ELISA, WB | Mouse IgG1 |
| HPAB-1502-FY | Mouse Anti-CXCL8 Recombinant Antibody (clone 1A1.4C6) | ELISA, WB | Mouse IgG1 |
| HPAB-1503-FY | Mouse Anti-CXCL8 Recombinant Antibody (clone 1L351.17) | ELISA, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201CL | Human Anti-CXCL8 Recombinant Antibody (TAB-201CL) | ELISA | Human IgG2 |
| TAB-701LC | Human Anti-CXCL8 Recombinant Antibody (TAB-701LC) | ELISA, FC, FuncS | Human IgG1, κ |
| TAB-701LC-S(P) | Human Anti-CXCL8 Recombinant Antibody; scFv Fragment (TAB-701LC-S(P)) | ELISA | Human scFv |
| TAB-701LC-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (TAB-701LC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-095LC | Recombinant Anti-Human CXCL8 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-164LC | Recombinant Anti-Human CXCL8 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-644CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL601) | ELISA, Neut | Mouse IgG1 |
| NEUT-645CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL602) | WB, ICC, Neut | Mouse IgG1 |
| NEUT-646CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL115) | FC, WB, IHC, Neut | Mouse IgG1 |
| NEUT-647CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone I8-60) | ELISA, Neut, WB | Mouse IgG1, κ |
| NEUT-648CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone I8-S2) | ELISA, Neut, WB | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-660CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone B-K8) | Block, ICFC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4128 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone SI199DS) | ELISA | Rabbit IgG |
| MOR-4624 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone TH137DS) | WB | Rabbit IgG |
| MOR-4625 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone TH138DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0059-YC-S(P) | Human Anti-CXCL8 Recombinant Antibody; scFv Fragment (HPAB-N0059-YC-S(P)) | FuncS | Human scFv |
| HPAB-1682-FY-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (HPAB-1682-FY-F(E)) | ELISA | Human Fab |
| HPAB-1683-FY-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (HPAB-1683-FY-F(E)) | ELISA | Human Fab |
| HPAB-1684-FY-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (HPAB-1684-FY-F(E)) | ELISA | Human Fab |
| HPAB-0664-YJ-S(P) | Mouse Anti-CXCL8 Recombinant Antibody (clone 5.12.14); scFv Fragment | ELISA, WB, Inhib, Antagonist | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0664-YJ-F(E) | Mouse Anti-CXCL8 Recombinant Antibody (clone 5.12.14); Fab Fragment | ELISA, WB, Inhib, Antagonist | Mouse Fab |
| HPAB-0665-YJ-F(E) | Human Anti-CXCL8 Recombinant Antibody (clone ch5.12.14); Fab Fragment | ELISA, WB, Inhib, Antagonist | Chimeric (mouse/human) Fab |
| HPAB-1841-FY-S(P) | Human Anti-CXCL8 Recombinant Antibody (clone WS-4); Fab Fragment | Inhib | Humanized Fab |
| HPAB-S0084-YC-F(E) | Mouse Anti-CXCL8 Recombinant Antibody (clone 6G4.2.5); Fab Fragment | ELISA, Inhib | Mouse Fab |
| HPAB-1544WJ-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (clone K2.2.1) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY593 | Anti-CXCL8 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC86 | Recombinant Anti-CXCL8 Eliminating Antibody, pH-Sensitive (K2.2 var.) | Antigen-Sweeping In Vivo. | Human lgG2 |
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