Anti-DENV4 E Recombinant Antibody (MRO-1125LC) (CAT#: MRO-1125LC)
This product is a recombinant chimpanzee antibody against Dengue virus. This antibody binds to the E protein of all four DENV serotypes and the ELISA titers of its Fab fragment to DENV-1~DENV-4 have the average value of 3.9 μg/mL. This product is efficient for cross-neutralization of DENV-1 and DENV-2 and neutralization of DENV-3, DENV-4 and the West Nile virus. This antibody product is envisioned to be useful for prophylactic and therapeutic studies of dengue and other flaviviruses-associated diseases.
Specific Inquiry
WB
Figure 1 Analysis of antigen specificity by radioimmunoprecipitation.
Radioactive ³⁵S-methionine-labeled lysates separately prepared from Vero cells infected with each of the DENV serotypes (D1 to D4) were used for immune precipitation with Fab 1A5 or Fab 1A10.
Chimpanzee Fab Fragments and a Derived Humanized Immunoglobulin G1 Antibody That Efficiently Cross-Neutralize Dengue Type 1 and Type 2 Viruses
WB
Figure 2 Binding of Fab 1A5 to DENVs and other flaviviruses as measured by Western blotting.
Approximately 10⁵ PFU of each virus was applied and separated by polyacrylamide gel electrophoresis.
Chimpanzee Fab Fragments and a Derived Humanized Immunoglobulin G1 Antibody That Efficiently Cross-Neutralize Dengue Type 1 and Type 2 Viruses
ELISA
Figure 3 Analysis of Fab binding to DENV-1 or DENV-2.
Fabs 1A5, 1B2, and 1A10 were affinity purified, biotinylated, and used for analysis of binding activity to DENV-1 or DENV-2 by competition ELISA in the presence of competing, unlabeled Fabs.
Chimpanzee Fab Fragments and a Derived Humanized Immunoglobulin G1 Antibody That Efficiently Cross-Neutralize Dengue Type 1 and Type 2 Viruses
Neut
Figure 4 In vitro neutralization of DENVs and other flaviviruses by humanized IgG1 1A5.
The neutralizing activity of IgG1 1A5 against DENV-1 strain Hawaii, DENV-2 strain New Guinea B, DENV-3 strain H87, DENV-4 strain 814669, JEV vaccine strain SA14-14-2, LGTV strain TP 21, and the WNV/DENV-4 chimera was analyzed by a PRNT.
Chimpanzee Fab Fragments and a Derived Humanized Immunoglobulin G1 Antibody That Efficiently Cross-Neutralize Dengue Type 1 and Type 2 Viruses
Specifications
- Host Species
- Chimpanzee
- Derivation
- Phage display library
- Type
- Chimpanzee antibody
- Specificity
- Dengue virus-4
- Clone
- 1A5
- Applications
- ELISA, WB, Neut
- Related Disease
- Dengue virus-4 infection
Applications
- Application Notes
- The DENV4 E antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Western Blot, Neutralization.
Target
- Alternative Names
- Dengue virus-4; DENV4; Dengue virus-4 envelope protein E; DENV4 E
- Gene ID
- 5075729
- UniProt ID
- P09866
- Long Name
- Dengue virus-4 envelope protein
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody Products
Mouse Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1118LC | Human Anti-DENV4 E Recombinant Antibody (MRO-1118LC) | ELISA | Human IgG |
| MRO-1118LC-S(P) | Human Anti-DENV4 E Recombinant Antibody; scFv Fragment (MRO-1118LC-S(P)) | ELISA | Human scFv |
| MRO-1118LC-F(E) | Human Anti-DENV4 E Recombinant Antibody; Fab Fragment (MRO-1118LC-F(E)) | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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