Mouse Anti-F2R Recombinant Antibody (clone 4E7.J14.L16)
CAT#: HPAB-0272-YC
The protease-activated receptor 1 (PAR1) is a thrombin receptor which belongs to the class of G protein-coupled receptors (GCPR). PAR1 is expressed in various tissues, such as endothelial cells, smooth muscles cells, fibroblasts, neurons and human platelets. It is involved in cellular responses associated with hemostasis, proliferation, and tissue injury.
Published Data
Gene Expression
Inhib
Figure 1 shows that thrombin stimulated secretion of IL-8 by HUVEC cells is inhibited by mouse anti-hPAR1 antibody clone 4E7.J14.L16.
FuncS
Figure 2 illustrates the strong antagonist activity of clone 4E7.J14, as measured in a calcium flux (FlipR) assay.
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Normal Tissue
Figure 1 Colon
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12962/34660_A_8_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12962/34660_A_9_5.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12962/34660_A_4_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12962/34660_A_9_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (hTERT-RPE1, HUVEC TERT2, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181104-F2R
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Specifications
- Immunogen
- Human PAR1 (AA #27-102)/thioredoxin fusion protein
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human F2R
- Species Reactivity
- Human
- Clone
- 4E7.J14.L16
- Applications
- ELISA, Stim
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Inhibition, Functional Assay.
Target
- Alternative Names
- F2R; coagulation factor II (thrombin) receptor; TR; HTR; CF2R; PAR1; PAR-1; proteinase-activated receptor 1; protease-activated receptor 1
- Gene ID
- 2149
- UniProt ID
- A0A024RAP7
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 4E7.J14.L16"
- CAT
- Product Name
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|---|---|---|---|
| MOB-345 | Recombinant Anti-human F2R Antibody | ELISA, WB, Neut, FuncS | IgG |
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| CAT | Product Name | Application | Type |
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| MOB-345-F(E) | Recombinant Anti-human F2R Antibody Fab Fragment | ELISA, IF, FuncS | Fab |
| MHH-345-F(E) | Recombinant Human Anti-human F2R Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| HPAB-0272-YC-F(E) | Mouse Anti-F2R Recombinant Antibody (clone 4E7.J14.L16); Fab Fragment | ELISA, Stim | Mouse Fab |
| CAT | Product Name | Application | Type |
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| MOB-345-S(P) | Recombinant Anti-human F2R Antibody scFv Fragment | Neut, IF, FuncS | scFv |
| MHH-345-S(P) | Recombinant Human Anti-human F2R Antibody scFv Fragment | FC, IP, FuncS | scFv |
| HPAB-0272-YC-S(P) | Mouse Anti-F2R Recombinant Antibody (clone 4E7.J14.L16); scFv Fragment | ELISA, Stim | Mouse scFv |
| CAT | Product Name | Application | Type |
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| TAB-0931CL-S(P) | Mouse Anti-F2R Recombinant Antibody; scFv Fragment (TAB-0931CL-S(P)) | ELISA | Mouse scFv |
| TAB-0932CL-S(P) | Mouse Anti-F2R Recombinant Antibody; scFv Fragment (TAB-0932CL-S(P)) | ELISA | Mouse scFv |
| TAB-0931CL-F(E) | Mouse Anti-F2R Recombinant Antibody; Fab Fragment (TAB-0931CL-F(E)) | ELISA | Mouse Fab |
| TAB-0932CL-F(E) | Mouse Anti-F2R Recombinant Antibody; Fab Fragment (TAB-0932CL-F(E)) | ELISA | Mouse Fab |
| TAB-0933CL-F(E) | Anti-Human F2R Recombinant Antibody Fab Fragment (PR15-5) | ELISA |
| CAT | Product Name | Application | Type |
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| VS-0425-YC593 | Recombinant Anti-F2R Vesicular Antibody, EV Displayed (VS-0425-YC593) | ELISA, FC, Stim, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY2408 | Anti-F2R Immunohistochemistry Kit | IHC | |
| VS-0525-XY2409 | Anti-Mouse F2R Immunohistochemistry Kit | IHC |
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