Mouse Anti-F2R Recombinant Antibody (clone 4E7.J14.L16) (CAT#: HPAB-0272-YC)
The protease-activated receptor 1 (PAR1) is a thrombin receptor which belongs to the class of G protein-coupled receptors (GCPR). PAR1 is expressed in various tissues, such as endothelial cells, smooth muscles cells, fibroblasts, neurons and human platelets. It is involved in cellular responses associated with hemostasis, proliferation, and tissue injury.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Inhib
Figure 1 shows that thrombin stimulated secretion of IL-8 by HUVEC cells is inhibited by mouse anti-hPAR1 antibody clone 4E7.J14.L16.
FuncS
Figure 2 illustrates the strong antagonist activity of clone 4E7.J14, as measured in a calcium flux (FlipR) assay.
Specifications
- Immunogen
- Human PAR1 (AA #27-102)/thioredoxin fusion protein
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human F2R
- Species Reactivity
- Human
- Clone
- 4E7.J14.L16
- Applications
- ELISA, Stim
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Inhibition, Functional Assay.
Target
- Alternative Names
- F2R; coagulation factor II (thrombin) receptor; TR; HTR; CF2R; PAR1; PAR-1; proteinase-activated receptor 1; protease-activated receptor 1
- Gene ID
- 2149
- UniProt ID
- A0A024RAP7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-345 | Recombinant Anti-human F2R Antibody | ELISA, WB, Neut, FuncS | IgG |
| MHH-345 | Recombinant Human Anti-human F2R Antibody | WB, FC, FuncS | IgG |
| VS7-HM921 | Mouse Anti-F2R Recombinant Antibody (clone 5E2E6) | IHC | Mouse IgG1 |
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