Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC27.01) (CAT#: PABL-184)
Recombinant Human Antibody (VRC27.01) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp160 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp160 mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody neutralized 78% of circulating HIV-1 isolates
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Figure 1 Flow cytometric identification of RSC3-reactive IgG+ B cells from donor 44, C38 and Z258. Gating and percentage of antigen-specific (RSC3+, ΔRSC3-) memory B cells (CD19+, CD20+, IgG+) are indicated. Neighbor-joining trees display the protein distance of gp160 sequences from 176 gp160 sequences. A scale bar denotes 5% distance in amino acid sequence. Tree branches are colored by the neutralization potencies of VRC13.01, VRC16.01, VRC18.02 and VRC27.01 against each virus.
Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A.,... & Ernandes, M. J. (2015). Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell, 161(6), 1280-1292.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Species Reactivity
- HIV-1
- Clone
- VRC27.01
- Applications
- FC, Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for FC. For details, refer to published data.
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160; precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Humanized Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-165 | Human Anti-HIV-1 gp120 Recombinant Antibody; Fab Fragment (PFBL-165) | Neut, ELISA, FuncS | Human Fab |
| PFBL-166 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone HJ16); Fab Fragment | Neut, FuncS | Human Fab |
| PFBL-167 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L1); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
| PFBL-168 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L3); Fab Fragment | WB, Neut, FuncS | Human Fab |
| PFBL-169 | Human Anti-HIV-1 gp120 Recombinant Antibody; Fab Fragment (PFBL-169) | WB, ELISA, IF, FuncS | Human Fab |
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