Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC18.02)
CAT#: PABL-183
Recombinant Human Antibody (VRC18.02) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp160 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp160 mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody neutralized 67% of circulating HIV-1 isolates
Published Data
Figure 1 Flow cytometric identification of RSC3-reactive IgG+ B cells from donor 44, C38 and Z258. Gating and percentage of antigen-specific (RSC3+, ΔRSC3-) memory B cells (CD19+, CD20+, IgG+) are indicated. Neighbor-joining trees display the protein distance of gp160 sequences from 176 gp160 sequences. A scale bar denotes 5% distance in amino acid sequence. Tree branches are colored by the neutralization potencies of VRC13.01, VRC16.01, VRC18.02 and VRC27.01 against each virus.
Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A.,... & Ernandes, M. J. (2015). Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell, 161(6), 1280-1292.
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Species Reactivity
- HIV-1
- Clone
- VRC18.02
- Applications
- FC, Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for FC. For details, refer to published data.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone VRC18.02"
- CAT
- Product Name
See other products for "HIV-1 gp160"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-177 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-177) | WB, ELISA, Neut, FuncS | Human IgG |
| PABL-178 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-178) | WB, ELISA, FuncS | Human IgG |
| PABL-179 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone PGT128) | WB, ELISA, FuncS | Human IgG |
| PABL-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08C) | WB, ELISA, Neut, FuncS | Human IgG, κ |
| PABL-181 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC13.01) | FC, Neut, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-180 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 2558); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-3741CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1H5); Fab Fragment | ELISA, WB | Human Fab |
| MRO-3742CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 4G2); Fab Fragment | ELISA, WB | Human Fab |
| MRO-3743CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 4B3); Fab Fragment | ELISA, WB | Human Fab |
| MRO-3744CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone H004364 (4364)); Fab Fragment | ELISA, IF, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-091LC | Anti-HIV-1 gp160 Recombinant Antibody (MAb CL1) | ELISA | Human antibody |
| MRO-091LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (MAb CL1) | ELISA | Human antibody |
| MRO-091LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (MAb CL1) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3741CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1H5); scFv Fragment | ELISA, WB | Human scFv |
| MRO-3742CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 4G2); scFv Fragment | ELISA, WB | Human scFv |
| MRO-3743CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 4B3); scFv Fragment | ELISA, WB | Human scFv |
| MRO-3744CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone H004364 (4364)); scFv Fragment | ELISA, IF, FC | Human scFv |
| MRO-3745CQ-S(P) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1324-E (1324E)); scFv Fragment | Neut | Human scFv |
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