Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) (CAT#: PABL-557)
Recombinant Human Antibody (Z258-VRC27.01) is capable of binding to HIV-1 gp160, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp160 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp160 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody neutralized 78% of HIV-1 strains.
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Figure 1 Flow cytometric identification of RSC3-reactive IgG+ B cells from a donor (donor Z258).
Gating and percentage of antigen-specific (RSC3+, ΔRSC3-) memory B cells (CD19+, CD20+, IgG+) are indicated. Sorted cells are in light gray while VRC27.01 and its respective clonal relatives are highlighted by colored dots.
Zhou, T., Lynch, R. M., Chen, L., Acharya, P., Wu, X., Doria-Rose, N. A., ... & Ernandes, M. J. (2015). Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors. Cell, 161(6), 1280-1292.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Tested positive against HIV-1 gp160
- Species Reactivity
- HIV-1
- Clone
- Z258-VRC27.01
- Applications
- FC Assay-dependent
Neut Assay-dependent
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Assay-dependent
Target
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-382 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08) | Neut, FuncS | Human IgG, κ |
| MRO-3778CQ | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 697-D (697D, 697-30D)) | Neut, Inhib, ELISA | Human IgG1, λ |
| MRO-3779CQ | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 1027-15D (1027, 1027-D, 1027D, 1027-15)) | ELISA | Human IgG1, λ |
| MRO-3780CQ | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 838-D (838)) | ELISA, Neut | Human IgG1, λ |
| MRO-3781CQ | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 43A3/E4) | ELISA | Human IgG2, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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