Anti-Human NGF Recombinant Antibody (Tanezumab) (CAT#: TAB-111)
Recombinant monoclonal antibody to NGF. Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor, as a treatment for pain.
Specific Inquiry
ELISA
Figure 1 ELISA assay with mNGF and hNGF coating (5 mg/ml) and serial dilutions of parental mAb aD11.
The experiments were done in duplicate.
Covaceuszach, S., Marinelli, S., Krastanova, I., Ugolini, G., Pavone, F., Lamba, D., & Cattaneo, A. (2012). Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody. PloS one, 7(3).
FuncS
Figure 2 Analgesic efficacy of mAb aD11 (one dose: 2 mg/kg) in the long lasting protocol of neuropathic pain model.
MAb aD11 increased the ipsilateral/contralateral index, starting either from day 5.
Covaceuszach, S., Marinelli, S., Krastanova, I., Ugolini, G., Pavone, F., Lamba, D., & Cattaneo, A. (2012). Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody. PloS one, 7(3).
Inhib
Figure 3 Hum-aD11 retains the biological activity of the parental mAb aD11.
mNGF induced differentiation of PC-12 cells.
Covaceuszach, S., Marinelli, S., Krastanova, I., Ugolini, G., Pavone, F., Lamba, D., & Cattaneo, A. (2012). Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody. PloS one, 7(3).
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG2
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- ELISA, FuncS, Inhib
- CAS
- 880266-57-9
- Generic Name
- Tanezumab
- UNII
- EQL0E9GCX1
- MW
- 145.4 kDa
- Related Disease
- Osteoarthritis (OA)
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The NGF antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.
Target
- Alternative Names
- Tanezumab;880266-57-9;RN624;RI-624;PF-04383119;muMab-911;RN624;NGF;nerve growth factor (beta polypeptide);NGFB;beta-nerve growth factor;nerve growth factor, beta subunit;HSAN5;Beta-NGF;MGC161426;MGC161428;
- Gene ID
- 4803
- UniProt ID
- P01138
Related Resources
Please refer to Tanezumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tanezumab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Tanezumab"
Afuco™ Anti-NGF ADCC Recombinant Antibody (Tanezumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to NGF. Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor, as a treatment for pain.
See other products for "Ngf"
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Humanized Antibody
Mouse Antibody
Human Antibody
Chimeric Antibody
Chicken IgY Antibody
Rabbit Monoclonal Antibody
Neutralizing Antibody
Blocking Antibody
scFv Fragment Antibody
Recombinant Antibody
ADCC Enhanced Antibody
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-686CL | Anti-Human NGF Therapeutical Antibody (PG110) | FuncS | Antibody |
| TAB-501MZ | Anti-Human NGF Recombinant Antibody (αD11. H67) | ELISA | Humanized antibody |
| TAB-501MZ-S(P) | Anti-Human NGF Recombinant Antibody scFv Fragment (αD11. H67) | ELISA, IRMA, RIA, IHC | Humanized antibody |
| TAB-501MZ-F(E) | Anti-Human NGF Recombinant Antibody Fab Fragment (αD11. H67) | ELISA, IRMA, RIA, IHC | Humanized antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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