Anti-Human NGF Recombinant Antibody (Tanezumab) (CAT#: TAB-111)

Recombinant monoclonal antibody to NGF. Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor, as a treatment for pain.

Host: Mouse

Isotype: IgG2

Applications: ELISA, FuncS, Inhib


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 ELISA assay with mNGF and hNGF coating (5 mg/ml) and serial dilutions of parental mAb aD11.

The experiments were done in duplicate.

Covaceuszach, S., Marinelli, S., Krastanova, I., Ugolini, G., Pavone, F., Lamba, D., & Cattaneo, A. (2012). Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody. PloS one, 7(3).

FuncS

Figure 2 Analgesic efficacy of mAb aD11 (one dose: 2 mg/kg) in the long lasting protocol of neuropathic pain model.

MAb aD11 increased the ipsilateral/contralateral index, starting either from day 5.

Covaceuszach, S., Marinelli, S., Krastanova, I., Ugolini, G., Pavone, F., Lamba, D., & Cattaneo, A. (2012). Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody. PloS one, 7(3).

Inhib

Figure 3 Hum-aD11 retains the biological activity of the parental mAb aD11.

mNGF induced differentiation of PC-12 cells.

Covaceuszach, S., Marinelli, S., Krastanova, I., Ugolini, G., Pavone, F., Lamba, D., & Cattaneo, A. (2012). Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody. PloS one, 7(3).


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG2
  • Specificity
  • Tested positive against native human antigen.
  • Species Reactivity
  • Human
  • Applications
  • ELISA, FuncS, Inhib
  • CAS
  • 880266-57-9
  • Generic Name
  • Tanezumab
  • UNII
  • EQL0E9GCX1
  • MW
  • 145.4 kDa
  • Related Disease
  • Osteoarthritis (OA)

Product Property

  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • The NGF antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.

Target

  • Alternative Names
  • Tanezumab;880266-57-9;RN624;RI-624;PF-04383119;muMab-911;RN624;NGF;nerve growth factor (beta polypeptide);NGFB;beta-nerve growth factor;nerve growth factor, beta subunit;HSAN5;Beta-NGF;MGC161426;MGC161428;

Related Resources

  • Biosimilar Overview
Please click here for more details about the introduction to mechanism of action, clinical projects and approved drugs of Tanezumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Tanezumab"

Afuco™ Anti-NGF ADCC Recombinant Antibody (Tanezumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to NGF. Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor, as a treatment for pain.

See other products for "NGF"

Humanized Antibody

CAT Product Name Application Type
TAB-686CL Anti-Human NGF Therapeutical Antibody (PG110) FuncS Antibody
TAB-501MZ Anti-Human NGF Recombinant Antibody (αD11. H67) ELISA Humanized antibody
TAB-501MZ-S(P) Anti-Human NGF Recombinant Antibody scFv Fragment (αD11. H67) ELISA, IRMA, RIA, IHC Humanized antibody
TAB-501MZ-F(E) Anti-Human NGF Recombinant Antibody Fab Fragment (αD11. H67) ELISA, IRMA, RIA, IHC Humanized antibody

Mouse Antibody

CAT Product Name Application Type
TAB-500MZ Anti-Human NGF Recombinant Antibody (MNAC13) ELISA, IRMA, RIA, IHC
TAB-502MZ Anti-Dog NGF Recombinant Antibody (NV-01) SDS-PAGE
TAB-503MZ Mouse Anti-NGF Recombinant Antibody (TAB-503MZ) ELISA Mouse IgG
TAB-504MZ Mouse Anti-NGF Recombinant Antibody (TAB-504MZ) ELISA Mouse IgG
TAB-505MZ Mouse Anti-NGF Recombinant Antibody (TAB-505MZ) ELISA Mouse IgG

Chimeric Antibody

CAT Product Name Application Type
TAB-509MZ Human Anti-NGF Recombinant Antibody (TAB-509MZ) ELISA Chimeric (mouse/human) IgG
TAB-509MZ-S(P) Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-509MZ-S(P)) ELISA Mouse scFv
TAB-510MZ-S(P) Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-510MZ-S(P)) ELISA Mouse scFv
TAB-509MZ-F(E) Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-509MZ-F(E)) ELISA Chimeric (mouse/human) Fab
TAB-510MZ-F(E) Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-510MZ-F(E)) ELISA Chimeric (mouse/human) Fab

Human Antibody

CAT Product Name Application Type
TAB-512MZ Human Anti-NGF Recombinant Antibody (TAB-512MZ) ELISA, RIA, FC, SPR, Inhib Human IgG
TAB-512MZ-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (TAB-512MZ-S(P)) ELISA, RIA, FC Human scFv
TAB-513MZ-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (TAB-513MZ-S(P)) ELISA, RIA, FC Human scFv
TAB-512MZ-F(E) Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-512MZ-F(E)) ELISA, RIA, FC Human Fab
TAB-513MZ-F(E) Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-513MZ-F(E)) ELISA, RIA, FC Human Fab

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0852MZ Chicken Anti-NGF Polyclonal IgY ELISA Chicken antibody
BRD-1134MZ Chicken Anti-Beta NGF Polyclonal IgY ELISA, WB, IHC Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
PABX-146-S (P) Rat Anti-NGF Recombinant Antibody (clone αD11) Neut, FC, FuncS Rat scFv
MOR-2439 Hi-Affi™ Recombinant Rabbit Anti-NGF Monoclonal Antibody (DS2439AB) WB, ICC, IHC-P, IHC-P IgG

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1764CQ Recombinant Mouse Anti-NGF Antibody (CBL293) Neut IgG1
NEUT-1765CQ Recombinant Mouse Anti-NGF Antibody (12A29) ELISA, Neut IgG1
NEUT-1766CQ Recombinant Mouse Anti-NGF Antibody (M85-2B) ELISA, Neut, WB IgG2b, κ
NEUT-1767CQ Recombinant Mouse Anti-Ngf Antibody (27/21) ELISA, Neut IgG1
NEUT-1769CQ Recombinant Mouse Anti-NGF Antibody (AS18) Neut IgG1

Blocking Antibody

CAT Product Name Application Type
NEUT-1768CQ Recombinant Mouse Anti-NGF Antibody (aD11) IF, BL, ELISA, IHC IgG1, κ
NEUT-1772CQ Recombinant Mouse Anti-NGF Antibody (25623.1) Dot, ELISA, Inhib IgG1

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0688-CN-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0688-CN-S(P)) WB, ELISA Human scFv
HPAB-0275CQ-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0275CQ-S(P)) ELISA, Neut Human scFv
HPAB-AP153-YC-S(P) Canine Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-AP153-YC-S(P)) ELISA, FuncS Canine scFv
HPAB-AP154-YC-S(P) Canine Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-AP154-YC-S(P)) ELISA, FuncS Canine scFv
HPAB-AP155-YC-S(P) Canine Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-AP155-YC-S(P)) ELISA, FuncS Canine scFv

Recombinant Antibody

CAT Product Name Application Type
HPAB-0275CQ Human Anti-NGF Recombinant Antibody (HPAB-0275CQ) ELISA, Neut, FuncS Human IgG2
PABC-401 Human Anti-NGF Recombinant Antibody (clone MEDI578) FuncS, ELISA, IHC Human IgG1
HPAB-0385-WJ Mouse Anti-NGF Recombinant Antibody (HPAB-0385-WJ) ELISA, FC, FuncS Mouse IgG
HPAB-0718-FY Mouse Anti-NGF Recombinant Antibody (clone AB020) ELISA Mouse IgG
HPAB-0727-FY Human Anti-NGF Recombinant Antibody (HPAB-0727-FY) Inhib Human IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-025ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Frunevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-031ML Afuco™ Anti-NGF ADCC Recombinant Antibody (Ranevetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody
AFC-TAB-111 Afuco™ Anti-NGF ADCC Recombinant Antibody (Tanezumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody
AFC-TAB-110 Afuco™ Anti-NGF Recombinant Antibody (AFC-TAB-110), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF Human IgG1, κ

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-N0190-YC-F(E) Human Anti-NGF Recombinant Antibody (clone NOV009YC); Fab Fragment ELISA Human Fab
HPAB-N0191-YC-F(E) Human Anti-NGF Recombinant Antibody (clone G11-H2L2); Fab Fragment ELISA, FuncS Human Fab
HPAB-0718-FY-S(P) Mouse Anti-NGF Recombinant Antibody (clone AB020); Fab Fragment ELISA Mouse Fab
HPAB-0727-FY-S(P) Human Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0727-FY-S(P)) Inhib Human scFv
HPAB-0893-FY-S(P) Canine Anti-NGF Recombinant Antibody; scFv Fragment (HPAB-0893-FY-S(P)) ELISA Canine scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
WBWestern Blot

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