Human Anti-ITGAL Recombinant Antibody (clone AL-57); scFv Fragment

CAT#: PSBW-159

Recombinant Human Antibody (AL-57) is capable of binding to ITGAL, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-ITGAL scFv and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-ITGAL proteins scFv and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. AL-57 functions as an ICAM-1 mimetic antibody that exhibits several key features of the ICAM-1/LFA-1 interaction. Not only do AL-57 and ICAM-1 both bind progressively better as LFA-1 affinity increases, they both require Mg2+ for binding.

Gene Expression
Figure 1 Bone marrow Figure 2 Lymph node Figure 3 RNA cell line category: Cell line enriched (HMC-1)

Specifications

  • Immunogen
  • Human integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human scFv
  • Specificity
  • Human ITGAL
  • Species Reactivity
  • Human
  • Clone
  • AL-57

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); CD11A; LFA-1; LFA1A; integrin alpha-L; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

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