Anti-Human CD11A Recombinant Antibody (TAB-024)
CAT#: TAB-024
Recombinant monoclonal antibody to Human CD11A. It is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis. As implied by the suffix -zumab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous injection. It binds to the CD11a subunit of lymphocyte function-associated antigen 1 and acts as an immunosuppressant by inhibiting lymphocyte activation and cell migration out of blood vessels into tissues. It was associated with fatal brain infections and was withdrawn from the market in 2009.
Gene Expression
Normal Tissue
Figure 1 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_B_5_4.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005844-ITGAL
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC, WB, Inhib
- Related Disease
- Psoriasis (infection in chronic moderate to severe plaque)
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Applications
- Application Notes
- The ITGAL antibody has been reported in applications of Neut, ELISA, IF, IP, FuncS, FC, WB, Inhib.
Target
- Alternative Names
- Efalizumab;raptiva;214745-43-4;hu1124;DB00095ITGAL;integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1;alpha polypeptide);CD11A;integrin alpha-L;LFA 1;LFA-1A;LFA-1 alpha;integrin gene promoter;CD11 antigen-like family member
- Gene ID
- 3683
- UniProt ID
- P20701
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Biosimilar Overview
Please refer to Efalizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Efalizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "ITGAL"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1129z | Mouse Anti-ITGAL Recombinant Antibody (clone 44C9) | IP, FC, FuncS | Mouse IgG1 |
| MOB-2281MZ | Recombinant Mouse Anti-Human ITGAL Antibody (clone C-C26) | FC | Mouse antibody |
| HPAB-0487-WJ | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1) | IP, ELISA | Mouse IgG |
| VS3-XY908 | Mouse Anti-ITGAL Recombinant Antibody, FITC (clone 4ATS1/22.1.1.13) | FC, IF | Mouse IgG1 |
| VS3-XY909 | Mouse Anti-ITGAL Recombinant Antibody, PE (clone 4ATS1/22.1.1.13) | FC, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-108 | Anti-Human CD11a Recombinant Antibody (TAB-108) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 |
| TAB-459CL | Mouse Anti-ITGAL Recombinant Antibody (TAB-459CL) | ELISA | Mouse IgG |
| TAB-1579CL | Rat Anti-ITGAL Recombinant Antibody (TAB-1579CL) | Block | Rat IgG2a, κ |
| TAB-1579CL-S(P) | Rat Anti-ITGAL Recombinant Antibody; scFv Fragment (TAB-1579CL-S(P)) | Block | Rat scFv |
| TAB-1579CL-F(E) | Rat Anti-ITGAL Recombinant Antibody; Fab Fragment (TAB-1579CL-F(E)) | Block | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); Fab Fragment | WB | Human Fab |
| NS-018CN-F(E) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); Fab Fragment | FC, ELISA | Human Fab |
| HPAB-0487-WJ-F(E) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); Fab Fragment | ELISA | Mouse Fab |
| HPAB-S0088-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); Fab Fragment | Inhib | Chimeric (mouse/human) Fab |
| HPAB-S0089-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); Fab Fragment | Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); scFv Fragment | WB | Human scFv |
| NS-018CN-S(P) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); scFv Fragment | FC, ELISA | Human scFv |
| HPAB-0487-WJ-S(P) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); scFv Fragment | ELISA | Mouse scFv |
| HPAB-S0088-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); scFv Fragment | Inhib | Mouse scFv |
| HPAB-S0089-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); scFv Fragment | Inhib | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-755LC | Anti-human ITGAL Recombinant Antibody (Chimeric S6F1) (TAB-755LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-755LC-S(P) | Anti-human ITGAL scFv Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
| TAB-755LC-F(E) | Anti-human ITGAL Fab Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1559CQ | Recombinant Mouse Anti-ITGAL Antibody (38) | FC, ICC, IF, IHC-Fr, IP, Neut | IgG2a |
| NEUT-1563CQ | Recombinant Mouse Anti-ITGAL Antibody (CBL227) | FC, IHC, IP, Neut | IgG2a |
| NEUT-1565CQ | Recombinant Rat Anti-Itgal Antibody (121/7) | FC, IP, Neut, WB | IgG2a |
| NEUT-1568CQ | Recombinant Rat Anti-Itgal Antibody (I21/7) | Neut, FC, IHC, IHC-Fr, IP, ICC | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1560CQ | Recombinant Mouse Anti-ITGAL Antibody (HI111) | FC, BL | IgG1, κ |
| NEUT-1561CQ | Recombinant Mouse Anti-ITGAL Antibody (MEM-83) | BL, FC, FuncS, IP | IgG1 |
| NEUT-1562CQ | Recombinant Mouse Anti-ITGAL Antibody (TS-1/22.1.1.13) | BL, FC | IgG1 |
| NEUT-1564CQ | Recombinant Mouse Anti-ITGAL Antibody (R7-1) | BL, FC | IgG1 |
| NEUT-1566CQ | Recombinant Rat Anti-Itgal Antibody (M17/4) | IP, IHC-Fr, FuncS, FC, BL | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1878 | Hi-Affi™ Recombinant Rabbit Anti-ITGAL Monoclonal Antibody (DS1878AB) | BL, FC, ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-018CN | Human Anti-ITGAL Recombinant Antibody (clone MHM24) | FC, ELISA, Inhib, FuncS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-108 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-108) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-024 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-024) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0066SW | Recombinant Llama Anti-ITGAL Single Domain Antibody (MOB-0066SW) | ELISA, WB | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY45 | Human Anti-ITGAL scFv-Fc Chimera (VS-0425-FY45) | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC352 | Recombinant Anti-ITGAL Vesicular Antibody, EV Displayed (VS-0425-YC352) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3640 | Anti-ITGAL Immunohistochemistry Kit | IHC |
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