Human Anti-ITGAL scFv-Fc Chimera (VS-0425-FY45)
CAT#: VS-0425-FY45
The anti-ITGAL scFv-Fc is a novel recombinant protein designed to target the integrin alpha L (ITGAL) molecule, which plays a crucial role in immune response and leukocyte adhesion. This product features a single-chain variable fragment (scFv) fused to an Fc region, enhancing its stability and efficacy in therapeutic applications. Its unique structure allows for a high affinity binding to ITGAL, making it a potent candidate for treating inflammatory diseases and certain types of cancer. Furthermore, the scFv-Fc format facilitates easier purification and can be engineered for improved pharmacokinetics. Researchers can utilize this product to explore its potential in cell adhesion studies and therapeutic interventions. Overall, the anti-ITGAL scFv-Fc represents a promising tool in the field of immunology and targeted therapy.
Gene Expression
Normal Tissue
Figure 1 Bone marrow
Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_B_5_4.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005844-ITGAL
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ITGAL
- Species Reactivity
- Human
- Applications
- Immunoassay
- Related Disease
- Neutropenia, Severe Congenital, X-Linked and Chronic Venous Insufficiency
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Integrin Subunit Alpha L
- Gene ID
- 3683
- UniProt ID
- P20701
- Long Name
- Integrin Subunit Alpha L
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
- Protein Refseq
- NP_001107852.1; NP_002200.2
- Function
- Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R.
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL.
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity.
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils.
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis.
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-024 | Anti-Human CD11A Recombinant Antibody (TAB-024) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-108 | Anti-Human CD11a Recombinant Antibody (TAB-108) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 |
| TAB-459CL | Mouse Anti-ITGAL Recombinant Antibody (TAB-459CL) | ELISA | Mouse IgG |
| TAB-1579CL | Rat Anti-ITGAL Recombinant Antibody (TAB-1579CL) | Block | Rat IgG2a, κ |
| TAB-1579CL-S(P) | Rat Anti-ITGAL Recombinant Antibody; scFv Fragment (TAB-1579CL-S(P)) | Block | Rat scFv |
| TAB-1579CL-F(E) | Rat Anti-ITGAL Recombinant Antibody; Fab Fragment (TAB-1579CL-F(E)) | Block | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); Fab Fragment | WB | Human Fab |
| NS-018CN-F(E) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); Fab Fragment | FC, ELISA | Human Fab |
| HPAB-0487-WJ-F(E) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); Fab Fragment | ELISA | Mouse Fab |
| HPAB-S0088-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); Fab Fragment | Inhib | Chimeric (mouse/human) Fab |
| HPAB-S0089-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); Fab Fragment | Inhib | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); scFv Fragment | WB | Human scFv |
| NS-018CN-S(P) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); scFv Fragment | FC, ELISA | Human scFv |
| HPAB-0487-WJ-S(P) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); scFv Fragment | ELISA | Mouse scFv |
| HPAB-S0088-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); scFv Fragment | Inhib | Mouse scFv |
| HPAB-S0089-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); scFv Fragment | Inhib | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-755LC | Anti-human ITGAL Recombinant Antibody (Chimeric S6F1) (TAB-755LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-755LC-S(P) | Anti-human ITGAL scFv Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
| TAB-755LC-F(E) | Anti-human ITGAL Fab Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2281MZ | Recombinant Mouse Anti-Human ITGAL Antibody (clone C-C26) | FC | Mouse antibody |
| FAMAB-1185CQ | Mouse Anti-ITGAL Recombinant Antibody (clone YTH 81.5) | FC | Mouse IgG1 |
| ZG-0880F | Mouse Anti-ITGAL Recombinant Antibody (clone OFYS) | FC | Mouse IgG2a |
| VS3-FY771 | Recombinant Rabbit Anti-Itgal Antibody (clone R08-3I4) | WB, IHC-P | Rabbit IgG |
| VS-0224-XY75 | Mouse Anti-ITGAL Recombinant Antibody (VS-0224-XY75) | WB, FC, IP, ICC, RIA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1559CQ | Recombinant Mouse Anti-ITGAL Antibody (38) | FC, ICC, IF, IHC-Fr, IP, Neut | IgG2a |
| NEUT-1563CQ | Recombinant Mouse Anti-ITGAL Antibody (CBL227) | FC, IHC, IP, Neut | IgG2a |
| NEUT-1565CQ | Recombinant Rat Anti-Itgal Antibody (121/7) | FC, IP, Neut, WB | IgG2a |
| NEUT-1568CQ | Recombinant Rat Anti-Itgal Antibody (I21/7) | Neut, FC, IHC, IHC-Fr, IP, ICC | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1560CQ | Recombinant Mouse Anti-ITGAL Antibody (HI111) | FC, BL | IgG1, κ |
| NEUT-1561CQ | Recombinant Mouse Anti-ITGAL Antibody (MEM-83) | BL, FC, FuncS, IP | IgG1 |
| NEUT-1562CQ | Recombinant Mouse Anti-ITGAL Antibody (TS-1/22.1.1.13) | BL, FC | IgG1 |
| NEUT-1564CQ | Recombinant Mouse Anti-ITGAL Antibody (R7-1) | BL, FC | IgG1 |
| NEUT-1566CQ | Recombinant Rat Anti-Itgal Antibody (M17/4) | IP, IHC-Fr, FuncS, FC, BL | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1878 | Hi-Affi™ Recombinant Rabbit Anti-ITGAL Monoclonal Antibody (DS1878AB) | BL, FC, ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-018CN | Human Anti-ITGAL Recombinant Antibody (clone MHM24) | FC, ELISA, Inhib, FuncS | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-108 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-108) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-024 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-024) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0066SW | Recombinant Llama Anti-ITGAL Single Domain Antibody (MOB-0066SW) | ELISA, WB | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC352 | Recombinant Anti-ITGAL Vesicular Antibody, EV Displayed (VS-0425-YC352) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3640 | Anti-ITGAL Immunohistochemistry Kit | IHC |
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