Afuco™ Anti-Human ITGB7 ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-445CL)
Anti-ITGB7 ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This is a humanized anti-human β7 monoclonal antibody currently in phase I in inflammatory bowel disease. It binds the β7 subunit of the integrins α4β7 and αEβ7, blocking interaction with their ligands. These integrins play key roles in immune cell homing to and retention in mucosal sites, and are associated with chronic inflammatory diseases of the gastrointestinal tract.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42277/476_E12_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42277/476_E12_1_selected.jpg
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139626-ITGB7
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139626-ITGB7
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Inflammatory Diseases
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- ITGB7; integrin, beta 7; integrin beta-7; integrin beta 7 subunit; gut homing receptor beta subunit
- Gene ID
- 3695
- UniProt ID
- P26010
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1593z | Mouse Anti-ITGB7 Recombinant Antibody (MOB-1593z) | IP, Block, FC | Mouse IgG2a |
| VS3-FY780 | Recombinant Mouse Anti-ITGB7 Antibody (clone 4C6B4H9) | ELISA, IHC, FC | Mouse IgG1 |
| VS7-0425-WR163 | Mouse Anti-ITGB7 Recombinant Antibody (clone 6A2G4) | IHC, ICC, FC | Mouse IgG1 |
| VS7-0425-WR164 | Mouse Anti-ITGB7 Recombinant Antibody (clone 4C5D2) | IHC, ICC, FC | Mouse IgG1 |
| VS7-0425-WR165 | Mouse Anti-ITGB7 Recombinant Antibody (clone 1B4A8) | IHC, FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
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