Anti-Human ITGB7 Recombinant Antibody (CAT#: TAB-463CL)
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human ITGB7. This is a humanized anti-human β7 monoclonal antibody currently in phase I in inflammatory bowel disease. It binds the β7 subunit of the integrins α4β7 and αEβ7, blocking interaction with their ligands. These integrins play key roles in immune cell homing to and retention in mucosal sites, and are associated with chronic inflammatory diseases of the gastrointestinal tract.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42277/476_E12_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42277/476_E12_1_selected.jpg
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139626-ITGB7
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139626-ITGB7
Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Inflammatory Diseases
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Target
- Alternative Names
- ITGB7; integrin, beta 7; integrin beta-7; integrin beta 7 subunit; gut homing receptor beta subunit
- Gene ID
- 3695
- UniProt ID
- P26010
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1593z | Mouse Anti-ITGB7 Recombinant Antibody (MOB-1593z) | IP, Block, FC | Mouse IgG2a |
| VS3-FY780 | Recombinant Mouse Anti-ITGB7 Antibody (clone 4C6B4H9) | ELISA, IHC, FC | Mouse IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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