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    Anti-human Integrin α5β1 Recombinant Antibody (3C5) (TAB-720LC) (CAT#: TAB-720LC)

    Recombinant monoclonal antibody 3C5 is a human monoclonal antibody that specifically binds to human integrin α5β1 and can be potentially used in the treatment of colon cancer and pancreatic cancer.

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    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Published Data
    • Datasheet
    • MSDS
    • COA
    Inhib

    Figure 1 A bar chart showing the effect of inhibitory α5β1 antibodies on the attachment of endothelial cells to fibronectin, in the presence of 10 μL/mL L230.

    Figure 1 A bar chart showing the effect of inhibitory α5β1 antibodies on the attachment of endothelial cells to fibronectin, in the presence of 10 μL/mL L230.

    Antibody treatments are indicated on the X-axis, and compared to a no treatment control. IgG1 control, 3C5 and 5B11 were used at 10 μg/ml and 25 μg/ml as indicated. The mean cell adhesion as measured by cell count is indicated on the Y-axis, together with the standard deviation of the mean (error bars).

    Inhib

    Figure 2 A bar chart showing the effect of inhibitory α5β1 antibodies on endothelial cell tube formation in an endothelial tube formation co-culture assay.

    Figure 2 A bar chart showing the effect of inhibitory α5β1 antibodies on endothelial cell tube formation in an endothelial tube formation co-culture assay.

    Antibodies are indicated on the X-axis and concentrations from left to right in each group of bars are 5 μg/mL, 1 μg/mL, 0.2 μg/mL and 0.04 μg/mL. The degree of tube formation in terms of length (mm) and bifurcations is shown on the Y-axis. The values represented are the mean +/-the standard deviation. Vessel length (mm) is represented in black bars and bifurcations in grey bars.

    Inhib

    Figure 3 A bar chart showing the effect of inhibitory α5β1 antibodies on angiogenesis in vivo.

    Figure 3 A bar chart showing the effect of inhibitory α5β1 antibodies on angiogenesis in vivo.

    Treatments are represented on the X-axis: Control vehicle twice weekly; 3C5 20 mg/kg twice weekly (diagonal stripped bars); 3C5 10 mg/kg twice weekly (checked bars); The Y axis shows mean vessel density +/-the standard error.


    Specifications

    • Immunogen
    • Human full-length α5βl
    • Host Species
    • Human
    • Type
    • Human antibody
    • Specificity
    • Human
    • Clone
    • 3C5
    • Applications
    • ELISA, FC, Inhib
    • Related Disease
    • Colon cancer and pancreatic cancer

    Applications

    • Application Notes
    • This antibody has been tested for use in Inhibition.

    Target

    • Alternative Names
    • Integrin α5β1; GPV/IIIa; GPV/IIa

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 3C5"

    See other products for "Integrin α5β1"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Human Antibodies Mouse Antibodies IgG Antibodies ScFv Antibodies Fab Antibodies
    CAT Product Name Application Type
    TAB-443CL Human Anti-Integrin α5β1 Recombinant Antibody (TAB-443CL) ELISA Human IgG
    TAB-719LC Anti-human Integrin α5β1 Recombinant Antibody (3C2.2A8) (TAB-719LC) ELISA, FC Human antibody
    TAB-721LC Anti-human Integrin α5β1 Recombinant Antibody (5B11) (TAB-721LC) ELISA, FC, Inhib Human antibody
    TAB-722LC Anti-human Integrin α5β1 Recombinant Antibody (MOR04055) (TAB-722LC) ELISA, FC, Block, Apop, FuncS Human antibody
    TAB-723LC Anti-human Integrin α5β1 Recombinant Antibody (MOR04624) (TAB-723LC) ELISA, FC, Block, Apop Human antibody

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