Anti-human Integrin α5β1 Recombinant Antibody (3C5) (TAB-720LC) (CAT#: TAB-720LC)

Figure 1 A bar chart showing the effect of inhibitory α5β1 antibodies on the attachment of endothelial cells to fibronectin, in the presence of 10 μL/mL L230.

Antibody treatments are indicated on the X-axis, and compared to a no treatment control. IgG1 control, 3C5 and 5B11 were used at 10 μg/ml and 25 μg/ml as indicated. The mean cell adhesion as measured by cell count is indicated on the Y-axis, together with the standard deviation of the mean (error bars).

Figure 2 A bar chart showing the effect of inhibitory α5β1 antibodies on endothelial cell tube formation in an endothelial tube formation co-culture assay.

Antibodies are indicated on the X-axis and concentrations from left to right in each group of bars are 5 μg/mL, 1 μg/mL, 0.2 μg/mL and 0.04 μg/mL. The degree of tube formation in terms of length (mm) and bifurcations is shown on the Y-axis. The values represented are the mean +/-the standard deviation. Vessel length (mm) is represented in black bars and bifurcations in grey bars.

Figure 3 A bar chart showing the effect of inhibitory α5β1 antibodies on angiogenesis in vivo.

Treatments are represented on the X-axis: Control vehicle twice weekly; 3C5 20 mg/kg twice weekly (diagonal stripped bars); 3C5 10 mg/kg twice weekly (checked bars); The Y axis shows mean vessel density +/-the standard error.