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    Anti-LPA Recombinant Antibody scFv Fragment (LT3015 [B7(LT3000, Lpathomab)]) (CAT#: TAB-0340CL-S(P))

    The high-affinity, specific monoclonal antibodies to LPA, one of which is also called Lpathpmab. The target of the antibody lysophosphatidic acid is a bioactive lipid mediating multiple cellular response, and it's involved in the establishment and progression of cancer by providing a pro-growth tumor microenvironment and promoting angiogenesis. By specifically react to LPA, the anti-LPA antbodies can be used in the treatment and prevention of malignancies, angiogenesis, and fibrosis-related disorders.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    • Published Data
    • Gene Expression
    • Datasheet
    • MSDS
    • COA

    Figure 1 LPA binding affinity measured as in Figure for native LT3015 (WT) and three LT3015 single point mutations.

    Figure 1 LPA binding affinity measured as in Figure for native LT3015 (WT) and three LT3015 single point mutations.

    Fleming, J. K., Wojciak, J. M., Campbell, M. A., & Huxford, T. (2011). Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. Journal of molecular biology, 408(3), 462-476.

    Figure 2 Site-directed mutagenesis and LPA binding assays of LT3015.

    Figure 2 Site-directed mutagenesis and LPA binding assays of LT3015.

    In comparison to native LT3015 (WT), the introduction of mutations in the LT3015 heavy chain (AsnH52Tyr/SerH52Tyr) or light chain (AnsL30Arg) does not significantly increase LPA affinity. However, their combination (AsnH52Tyr/SerH54Tyr/AsnL30Arg) results in a modified version of the antibody with increased LPA binding affinity.

    Fleming, J. K., Wojciak, J. M., Campbell, M. A., & Huxford, T. (2011). Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. Journal of molecular biology, 408(3), 462-476.


    Specifications

    • Host Species
    • Human
    • Type
    • Humanized Antibody
    • Clone
    • LT3015 [B7(LT3000, Lpathomab)]
    • Related Disease
    • Macular degeneration, pain-related disorders, malignancies, angiogenesis, fibrosis-related disorders

    Target

    • Alternative Names
    • LPA; Lysophosphatidic acid

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    See other products for "Clone LT3015 [B7(LT3000, Lpathomab)]"

    See other products for "LPA"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products ScFv Antibody Products Humanized Antibody Products Rabbit Monoclonal Antibody Products Fab Antibody Products
    CAT Product Name Application Type
    PABL-329 Recombinant Human Anti-S. aureus LPA Antibody WB, ELISA, FuncS IgG
    HPAB-0253-YC Mouse Anti-LPA Recombinant Antibody (clone 2D1) ELISA, WB Mouse IgG
    HPAB-0254-YC Mouse Anti-LPA Recombinant Antibody (clone B3) ELISA, FuncS Mouse IgG
    HPAB-0255-YC Human Anti-LPA Recombinant Antibody (clone hB3) ELISA, FuncS Humanized IgG
    ZG-0295F Mouse Anti-LPA Recombinant Antibody (ZG-0295F) WB, IHC, ELISA Mouse IgG

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