Recombinant Mouse Antibody (HyHEL-26) Fab Fragment is specific to Chicken LYZ. The HEL epitope recognized by H26 consists of 18 residues from three separate ploypeptide segments of the antigen that from a contiguous patch on its surface.
Figure 1 Summary of the effects on binding affinity with introduction of individual somatic mutations into the L-chains of H26L26 (black) and H8L26 (gray) antibodies.
Acchione, M., Lipschultz, C. A., DeSantis, M. E., Shanmuganathan, A., Li, M., Wlodawer, A., ... & Smith-Gill, S. J. (2009). Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies. Molecular immunology, 47(2-3), 457-464.
Figure 2 Antigen inhibition results with HH8 (solid), HH10 (diagonal), and HH26 (open), using panels of natural and site-specific mutants of lysozyme with mutations at (A) R21 and (B) D101.
The results are presented as the -log of the molar concentration which gave 50% inhibition of binding by the respective mAb to HEL.
Lavoie, T. B., Mohan, S., Lipschultz, C. A., Grivel, J. C., Li, Y., Mainhart, C. R., ... & Smith-Gill, S. J. (1999). Structural differences among monoclonal antibodies with distinct fine specificities and kinetic properties. Molecular immunology, 36(17), 1189-1205.
Figure 3 Kinetics of HH8, HH10, and HH26 association with wild type and mutant lysozymes
Lavoie, T. B., Mohan, S., Lipschultz, C. A., Grivel, J. C., Li, Y., Mainhart, C. R., ... & Smith-Gill, S. J. (1999). Structural differences among monoclonal antibodies with distinct fine specificities and kinetic properties. Molecular immunology, 36(17), 1189-1205.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-267 | Human Anti-LYZ Recombinant Antibody (clone HYHEL-10) | WB, IHC, FuncS | Human IgG |
PABL-268 | Mouse Anti-LYZ Recombinant Antibody (clone HYHEL-63) | WB, ELISA, FuncS | Mouse IgG |
PABZ-015 | Mouse Anti-LYZ Recombinant Antibody (clone HyHEL-5) | WB, FuncS | Mouse IgG |
PABZ-022 | Mouse Anti-LYZ Recombinant Antibody (clone D44.1) | WB, IF, FuncS | Mouse IgG |
PABW-022 | Human Anti-LYZ Recombinant Antibody (clone dAb HEL4) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PNBL-023 | Recombinant Anti-Human LYZ VHH Single Domain Antibody (cAbHuL5) | WB, ELISA, FuncS | Llama VHH |
PNBL-024 | Recombinant Anti-Chicken LYZ VHH Single Domain Antibody () | WB, ELISA, FuncS | Llama VHH |
PNBL-036 | Recombinant Anti-Chicken LYZ VHH Single Domain Antibody (1D2L19) | WB, FuncS | Llama VHH |
PNBL-051 | Recombinant Anti-Chicken LYZ VHH Single Domain Antibody (cAbBCII-10) | ELISA | Llama VHH |
PNBL-052 | Recombinant Anti-LYZ (D67H) VHH Single Domain Antibody (cAb-HuL6) | WB, ELISA, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-022 | Mouse Anti-LYZ Recombinant Antibody (clone D44.1); Fab Fragment | WB, IF, FuncS | Mouse Fab |
PFBW-022 | Human Anti-LYZ Recombinant Antibody (clone dAb HEL4); Fab Fragment | ELISA | Human Fab |
PFBC-023 | Mouse Anti-LYZ Recombinant Antibody (clone F10.6.6); Fab Fragment | WB, IF, FuncS | Mouse Fab |
PFBZ-023 | Mouse Anti-LYZ Recombinant Antibody (clone F9.13.7); Fab Fragment | WB, IHC, IF, FuncS | Mouse Fab |
PFBW-023 | Human Anti-LYZ Recombinant Antibody (clone HuLys11); Fab Fragment | WB, ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-102 | Mouse Anti-LYZ Recombinant Antibody (clone D11.15); scFv Fragment | ELISA | Mouse scFv |
PSBL-426 | Human Anti-LYZ Recombinant Antibody; scFv Fragment | WB, IF, FuncS | Human scFv |
MOB-111YJL-S(P) | Human Anti-LYZ Recombinant Antibody (clone HYHEL-10 Y53D); scFv Fragment | ELISA, FC, IHC | Human scFv |
MOB-112YJL-S(P) | Human Anti-LYZ Recombinant Antibody (clone HYHEL-10 Y53D,Y58F); scFv Fragment | ELISA, FC, IHC | Human scFv |
PSBS-0138 | Human Anti-LYZ Recombinant Antibody (Clone 01JF38); scFv Fragment | ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-073 | Recombinant Human Anti-Lysozyme Antibody (HuLys) | WB, ELISA, FuncS | IgG |
PABX-073-F (E) | Recombinant Human Anti-Lysozyme Antibody Fab Fragment (HuLys) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-138 | Recombinant Human Anti-Lysozyme Antibody | WB, Neut, FuncS | IgG |
PABX-138-S (P) | Recombinant Human Anti-Lysozyme Antibody scFv Fragment | WB, Neut, FuncS | scFv |
PABX-139-S (P) | Mouse Anti-LYZ Recombinant Antibody; scFv Fragment (PABX-139-S (P)) | WB, ELISA, FuncS | Mouse scFv |
PABX-138-F (E) | Recombinant Human Anti-Lysozyme Antibody Fab Fragment | WB, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-139 | Mouse Anti-LYZ Recombinant Antibody (PABX-139) | WB, ELISA, FuncS | Mouse IgG |
PABX-073-S (P) | Recombinant Human Anti-Lysozyme Antibody scFv Fragment (HuLys) | WB, ELISA, FuncS | scFv |
PABX-074-S (P) | Recombinant Mouse Anti-Lysozyme Antibody scFv Fragment (HyHEL-5) | WB, ELISA, FuncS | scFv |
PABX-074-F (E) | Recombinant Mouse Anti-Lysozyme Antibody Fab Fragment (HyHEL-5) | WB, ELISA, FuncS | Fab |
PABX-139-F (E) | Mouse Anti-LYZ Recombinant Antibody; Fab Fragment (PABX-139-F (E)) | WB, ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2112 | Hi-Affi™ Recombinant Rabbit Anti-LYZ Monoclonal Antibody (DS2112AB) | ICC, IHC-P, IP, WB | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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