Afuco™ Anti-Human MAG ADCC Recombinant Antibody, ADCC Enhanced (CAT#: AFC-490CL)
Anti-MAG ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. AFC-490CL is an investigational drug intended to help repair brain injury, appears to be safe for patients with stroke, according to a phase I/II study. The drug is a monoclonal antibody that blocks myelin-associated glycoprotein to promote neurite outgrowth and protect oligodendrocytes. Serious adverse events were reported in 10 of 42 subjects and were distributed evenly among three treatment groups. Local investigators considered three of the serious adverse events to be potentially drug-related. No adverse event was fatal. One patient in the high-dose group had acute renal failure 18 days after stroke onset and a second stroke 38 days after stroke onset. One patient in the moderate-dose group had dysgeusia.
Specific Inquiry
Figure 1 Staining for GSK249320 in the ipsilesional hemisphere.
Cash, D., Easton, A. C., Mesquita, M., Beech, J., Williams, S., Lloyd, A., ... & Cramer, S. C. (2016). GSK249320, a monoclonal antibody against the axon outgrowth inhibition molecule myelin-associated glycoprotein, improves outcome of rodents with experimental stroke. Journal of neurology and experimental neuroscience, 2(2), 28.
Figure 2 Box-and-whisker plots of gait velocity change over time and maximum value for the 2 treatment arms (intent-to-treat group).
Cramer, S. C., Enney, L. A., Russell, C. K., Simeoni, M., & Thompson, T. R. (2017). Proof-of-concept randomized trial of the monoclonal antibody GSK249320 versus placebo in stroke patients. Stroke, 48(3), 692-698.
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Stroke
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- MAG; myelin associated glycoprotein; GMA; S-MAG; SIGLEC4A; SIGLEC-4A; myelin-associated glycoprotein; sialic acid binding Ig-like lectin 4A; sialic acid-binding immunoglobulin-like lectin 4A
- Gene ID
- 4099
- UniProt ID
- P20916
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1161z | Mouse Anti-MAG Recombinant Antibody (clone 32F9) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| HPAB-0032-LS | Human Anti-MAG Recombinant Antibody | ELISA | Chimeric (mouse/human) IgG1, κ |
| HPAB-J0175-YC | Mouse Anti-MAG Recombinant Antibody (clone muAP022/YC) | ELISA | Mouse IgG |
| HPAB-J0176-YC | Human Anti-MAG Recombinant Antibody (clone chAP022/YC) | ELISA | Chimeric (mouse/human) IgG1 |
| HPAB-J0177-YC | Human Anti-MAG Recombinant Antibody (clone BVh3/CVI3) | ELISA, FuncS | Humanized (mouse/human) IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1720CQ | Recombinant Mouse Anti-Mag Antibody (CBL528) | WB, Neut | IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2121 | Hi-Affi™ Recombinant Rabbit Anti-MAG Monoclonal Antibody (DS2121AB) | WB, IP, FC | IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-447CQ | Anti-Human MAG Recombinant Antibody (Refanezumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0032-LS-F(E) | Mouse Anti-MAG Recombinant Antibody; Fab Fragment | ELISA | Mouse Fab |
| HPAB-0033-LS-F(E) | Human Anti-MAG Recombinant Antibody (clone BVh1/CVl1); Fab Fragment | ELISA, Neut | Human Fab |
| HPAB-J0175-YC-F(E) | Mouse Anti-MAG Recombinant Antibody (clone muAP022/YC); Fab Fragment | ELISA | Mouse Fab |
| HPAB-J0176-YC-F(E) | Human Anti-MAG Recombinant Antibody (clone chAP022/YC); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
| HPAB-J0177-YC-F(E) | Human Anti-MAG Recombinant Antibody (clone BVh3/CVI3); Fab Fragment | ELISA | Humanized (mouse/human) Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0032-LS-S(P) | Mouse Anti-MAG Recombinant Antibody; scFv Fragment | ELISA | Mouse scFv |
| HPAB-0033-LS-S(P) | Human Anti-MAG Recombinant Antibody (clone BVh1/CVl1); scFv Fragment | ELISA, Neut | Human scFv |
| HPAB-J0175-YC-S(P) | Mouse Anti-MAG Recombinant Antibody (clone muAP022/YC); scFv Fragment | ELISA | Mouse scFv |
| HPAB-J0176-YC-S(P) | Human Anti-MAG Recombinant Antibody (clone chAP022/YC); scFv Fragment | ELISA | Mouse scFv |
| HPAB-J0177-YC-S(P) | Human Anti-MAG Recombinant Antibody (clone BVh3/CVI3); scFv Fragment | ELISA | Humanized (mouse/human) scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-447CQ | Afuco™ Anti-MAG ADCC Recombinant Antibody (Refanezumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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