Afuco™ Anti-Human MAG ADCC Recombinant Antibody, ADCC Enhanced
CAT#: AFC-490CL
Anti-MAG ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. AFC-490CL is an investigational drug intended to help repair brain injury, appears to be safe for patients with stroke, according to a phase I/II study. The drug is a monoclonal antibody that blocks myelin-associated glycoprotein to promote neurite outgrowth and protect oligodendrocytes. Serious adverse events were reported in 10 of 42 subjects and were distributed evenly among three treatment groups. Local investigators considered three of the serious adverse events to be potentially drug-related. No adverse event was fatal. One patient in the high-dose group had acute renal failure 18 days after stroke onset and a second stroke 38 days after stroke onset. One patient in the moderate-dose group had dysgeusia.
Published Data
Gene Expression
Figure 1 Staining for GSK249320 in the ipsilesional hemisphere.
Cash, D., Easton, A. C., Mesquita, M., Beech, J., Williams, S., Lloyd, A., ... & Cramer, S. C. (2016). GSK249320, a monoclonal antibody against the axon outgrowth inhibition molecule myelin-associated glycoprotein, improves outcome of rodents with experimental stroke. Journal of neurology and experimental neuroscience, 2(2), 28.
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Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9345/26620_B_9_5.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
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Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Stroke
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| TAB-447CQ | Anti-Human MAG Recombinant Antibody (Refanezumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
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|---|---|---|---|
| HPAB-0032-LS-F(E) | Mouse Anti-MAG Recombinant Antibody; Fab Fragment | ELISA | Mouse Fab |
| HPAB-0033-LS-F(E) | Human Anti-MAG Recombinant Antibody (clone BVh1/CVl1); Fab Fragment | ELISA, Neut | Human Fab |
| HPAB-J0175-YC-F(E) | Mouse Anti-MAG Recombinant Antibody (clone muAP022/YC); Fab Fragment | ELISA | Mouse Fab |
| HPAB-J0176-YC-F(E) | Human Anti-MAG Recombinant Antibody (clone chAP022/YC); Fab Fragment | ELISA | Chimeric (mouse/human) Fab |
| HPAB-J0177-YC-F(E) | Human Anti-MAG Recombinant Antibody (clone BVh3/CVI3); Fab Fragment | ELISA | Humanized (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0032-LS-S(P) | Mouse Anti-MAG Recombinant Antibody; scFv Fragment | ELISA | Mouse scFv |
| HPAB-0033-LS-S(P) | Human Anti-MAG Recombinant Antibody (clone BVh1/CVl1); scFv Fragment | ELISA, Neut | Human scFv |
| HPAB-J0175-YC-S(P) | Mouse Anti-MAG Recombinant Antibody (clone muAP022/YC); scFv Fragment | ELISA | Mouse scFv |
| HPAB-J0176-YC-S(P) | Human Anti-MAG Recombinant Antibody (clone chAP022/YC); scFv Fragment | ELISA | Mouse scFv |
| HPAB-J0177-YC-S(P) | Human Anti-MAG Recombinant Antibody (clone BVh3/CVI3); scFv Fragment | ELISA | Humanized (mouse/human) scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-447CQ | Afuco™ Anti-MAG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-447CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY155 | Human Anti-MAG scFv-Fc Chimera (VS-0425-FY155) | Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC668 | Recombinant Anti-MAG Vesicular Antibody, EV Displayed (VS-0425-YC668) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4168 | Anti-MAG Immunohistochemistry Kit | IHC | |
| VS-0525-XY4169 | Anti-Mouse MAG Immunohistochemistry Kit | IHC |
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