Anti-Human MAG Recombinant Antibody (CAT#: TAB-510CL)
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human MAG. TAB-510CL is an investigational drug intended to help repair brain injury, appears to be safe for patients with stroke, according to a phase I/II study. The drug is a monoclonal antibody that blocks myelin-associated glycoprotein to promote neurite outgrowth and protect oligodendrocytes. Serious adverse events were reported in 10 of 42 subjects and were distributed evenly among three treatment groups. Local investigators considered three of the serious adverse events to be potentially drug-related. No adverse event was fatal. One patient in the high-dose group had acute renal failure 18 days after stroke onset and a second stroke 38 days after stroke onset. One patient in the moderate-dose group had dysgeusia.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9345/26620_B_9_5.jpg
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9345/26620_B_9_5.jpg
Figure 2 RNA cell line category: Cell line enriched (WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
Figure 2 RNA cell line category: Cell line enriched (WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Related Disease
- Stroke
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- MAG; myelin associated glycoprotein; GMA; S-MAG; SIGLEC4A; SIGLEC-4A; myelin-associated glycoprotein; sialic acid binding Ig-like lectin 4A; sialic acid-binding immunoglobulin-like lectin 4A
- Gene ID
- 4099
- UniProt ID
- P20916
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1161z | Mouse Anti-MAG Recombinant Antibody (clone 32F9) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| HPAB-0032-LS | Human Anti-MAG Recombinant Antibody | ELISA | Chimeric (mouse/human) IgG1, κ |
| HPAB-0033-LS | Human Anti-MAG Recombinant Antibody (clone BVh1/CVl1) | ELISA, Neut | Chimeric (mouse/human) IgG1, κ |
| HPAB-J0175-YC | Mouse Anti-MAG Recombinant Antibody (clone muAP022/YC) | ELISA | Mouse IgG |
| HPAB-J0176-YC | Human Anti-MAG Recombinant Antibody (clone chAP022/YC) | ELISA | Chimeric (mouse/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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