anti-MME immunotoxin SN5d (IgG)-RTA
CAT#: AGTO-L034R
This immunotoxin was achieved by conjugating/fusing the Anti-MME monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to acute lymphoblastic leukemias (ALL) cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of acute lymphoblastic leukemias (ALL).
Gene Expression
Normal Tissue
Figure 1 Duodenum
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Normal Tissue
Figure 2 High expression in small intestine
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- SN5d
- Molecule Class
- IgG-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Acute lymphoblastic leukemias (ALL)
Target
- Alternative Names
- MME; membrane metallo-endopeptidase; NEP; SFE; CD10; CALLA; neprilysin; enkephalinase; atriopeptidase; neprilysin-390; neprilysin-411; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); Acute lymphoblastic leukemia; ALL; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 4311
- UniProt ID
- P08473
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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|---|---|---|---|
| MOB-1454z | Mouse Anti-MME Recombinant Antibody (clone 24C6) | WB, FC, IF, IHC | Mouse IgG1, κ |
| HPAB-0311-YJ | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5) | IHC, ELISA, WB | Mouse IgG2a |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L033R | anti-MME immunotoxin SN5d (Fab)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2246 | Hi-Affi™ Recombinant Rabbit Anti-MME Monoclonal Antibody (DS2246AB) | ICC, IF, WB | IgG |
| CAT | Product Name | Application | Type |
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| HPAB-0244-FY-S(P) | Recombinant Human Anti-MME Antibody scFv Fragment | F | Human scFv |
| HPAB-0311-YJ-S(P) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); scFv Fragment | IHC, ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
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| HPAB-0244-FY-F(E) | Recombinant Human Anti-MME Antibody Fab Fragment | F | Human Fab |
| HPAB-0311-YJ-F(E) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); Fab Fragment | IHC, ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY1083 | Mouse Anti-MME Recombinant Antibody (clone 307CT12.12.5) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
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| VS-0724-YC682 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC682) | IP, Protein Purification | |
| VS-0724-YC779 | AbPlus™ Anti-MME Magnetic Beads (VS-0724-YC779) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC720 | Recombinant Anti-MME Vesicular Antibody, EV Displayed (VS-0425-YC720) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4431 | Anti-MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4432 | Anti-Mouse MME Immunohistochemistry Kit | IHC | |
| VS-0525-XY4433 | Anti-Rat MME Immunohistochemistry Kit | IHC |
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