Anti-Human NOTUM Recombinant Antibody (SC2.D2.2) (CAT#: TAB-564MZ)
This human Notum neutralizing monoclonal antibody is able to block the Notum activity and impairs Notum mediated proliferation. It does not inhibit the activity of either murine Notum or macaque Notum.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
Figure 1 are graphical representations of a canonical Wnt3A assay as used to measure the effects of Notum modulators SC2.D2.2 and SC2.A106 (aka 10B3) on soluble Notum constructs Notum-His and Notum-hFc at various concentrations as normalized against uninhibited Wnt-induced luciferase activity.
Figure 2 illustrates the ability of the disclosed Notum modulators to inhibit the esterase activity of hNotum in vitro.
Figure 3 illustrates the ability of the disclosed Notum modulators to inhibit the lipase activity of hNotum in vitro where the concentration of hNotum is held constant and the concentration of the Notum modulator is varied.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- SC2.D2.2
- Applications
- FuncS, Inhib
- Related Disease
- Hyperproliferative disorders
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Inhibition.
Target
- Alternative Names
- NOTUM; notum pectinacetylesterase homolog (Drosophila); protein notum homolog
- Gene ID
- 147111
- UniProt ID
- Q6P988
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone SC2.D2.2"
See other products for "NOTUM"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-565MZ | Anti-Human NOTUM Recombinant Antibody (SC2.A106) | FuncS | |
TAB-564MZ-S(P) | Anti-Human NOTUM Recombinant Antibody scFv Fragment (SC2.D2.2) | ELISA | |
TAB-565MZ-S(P) | Anti-Human NOTUM Recombinant Antibody scFv Fragment (SC2.A106) | ELISA | |
TAB-567MZ-S(P) | Mouse Anti-NOTUM Recombinant Antibody; scFv Fragment (TAB-567MZ-S(P)) | ELISA | Mouse scFv |
TAB-568MZ-S(P) | Mouse Anti-NOTUM Recombinant Antibody; scFv Fragment (TAB-568MZ-S(P)) | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
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