Anti-Human PGE2 Recombinant Antibody (2B5) (CAT#: TAB-1022CL)

This antibody has high affinity for prostaglandin E2 and can neutralize prostaglandin E2 activity in vitro and in vivo.


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Figure 1 Analgesic effect of 2B5 in PBQ-treated mice.

Figure 1 Analgesic effect of 2B5 in PBQ-treated mice.

The dorsoflexion response to PBQ was induced in Swiss Webster mice. Ascites preparations of 2B5 and MOPC 21 were injected i.p. at the indicated doses 18 h before PBQ injection; indomethacin was administered by oral gavage 1 h before PBQ. Data are presented as the mean number of dorsoflexions ± SEM, n = 8/group. The mean number of dorsoflexions ± SEM of mice treated with PBQ alone was 48 ± 4.

Mnich, S. J., Veenhuizen, A. W., Monahan, J. B., Sheehan, K. C., Lynch, K. R., Isakson, P. C., & Portanova, J. P. (1995). Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2. The Journal of Immunology, 155(9), 4437-4444.

Figure 2 Analgesic effect of 2B5 in PBQ-treated mice.

Figure 2 Analgesic effect of 2B5 in PBQ-treated mice.

The protocol used for induction of nociception in fasted Swiss Webster mice is diagrammed beneath the figure. 2B5 and MOPC21 were injected in the form of ascites fluids 18 h before PBQ injection, n = 10 mice/group. *, significantly different from MOPC21-treated group, p < 0.05 by t-test.

Mnich, S. J., Veenhuizen, A. W., Monahan, J. B., Sheehan, K. C., Lynch, K. R., Isakson, P. C., & Portanova, J. P. (1995). Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2. The Journal of Immunology, 155(9), 4437-4444.

ELISA

Figure 1 Time course of 2B5 absorption in rat plasma.

Figure 1 Time course of 2B5 absorption in rat plasma.

The circulating level of the mouse anti-PGE mAb 2B5 (lgGl,K) was measured in rat plasma at indicated times after injection.

Portanova, J. P., Zhang, Y., Anderson, G. D., Hauser, S. D., Masferrer, J. L., Seibert, K., ... & Isakson, P. C. (1996). Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. The Journal of experimental medicine, 184(3), 883-891.

FuncS

Figure 2 2B5 and indomethacin reduce carrageenan-induced hyperalgesia.

Figure 2 2B5 and indomethacin reduce carrageenan-induced hyperalgesia.

Sprague Dawley rats were treated with 2B5, MOPC21.

Portanova, J. P., Zhang, Y., Anderson, G. D., Hauser, S. D., Masferrer, J. L., Seibert, K., ... & Isakson, P. C. (1996). Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. The Journal of experimental medicine, 184(3), 883-891.


Specifications

  • Immunogen
  • A prostaglandin E2-thyroglobulin conjugate
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • 2B5
  • Applications
  • FuncS, ELISA
  • Related Disease
  • Disorders in which prostaglandin E2 activity is detrimental

Applications

  • Application Notes
  • The PGE2 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Functional Assay.

Target

  • Alternative Names
  • PGE2; Prostaglandin E2; PGE2

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Chimeric Antibody

CAT Product Name Application Type
TAB-1023CL Anti-Human PGE2 Recombinant Antibody (2B5-7.0) ELISA Chimeric antibody (mouse/human)
TAB-1023CL-S(P) Anti-Human PGE2 Recombinant Antibody scFv Fragment (2B5-7.0) ELISA Chimeric antibody (mouse/human)
TAB-1023CL-F(E) Anti-Human PGE2 Recombinant Antibody Fab Fragment (2B5-7.0) ELISA Chimeric antibody (mouse/human)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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