What is the format of this anti-PGE2 antibody?

This product is a Recombinant Mouse scFv (single-chain variable fragment) antibody. It is produced in E. coli and is designed to bind to Prostaglandin E2 (PGE2), offering a smaller size compared to full-length antibodies.

Can this antibody be used for neutralization assays?

Yes, this antibody has been tested for Neutralization (Neut) applications, as well as Functional Studies (FuncS). It can neutralize the bioactivity of PGE2 in assay-dependent contexts.

Recombinant Mouse Anti-Prostaglandin E2 Antibody scFv Fragment (PGE2)

CAT#: PABX-160-S (P)

Anti-Prostaglandin E2 antibody is a Mouse of scFv class that binds to an Prostaglandin E2.

Published Data

Figure 1 PGE2 results in deacetylation of chromatin associated with the 16-PGDH gene promoter.

(A) Chromatin immunoprecipitation (IP) of acetylated histone H3 (AcH3) is compared with IP of IgG (negative control) in cells treated with DMSO or PGE2 (100 nM) for 24 h. Data represent average fold enrichment. *P < 0.06 compared with DMSO, Student's t te. n = 3. (B) Representative immunoblot and quantitation of 15-PGDH levels in hCSCs treated with DMSO or HDACi SAHA (2.5 μM), TSA (1 μM), or HDAC-42 (1 μM) for 24 h. Acetylated histone H3(AcH3), positive control; β-actin, loading control. *P < 0.05 compared with DMSO, Student's t test. n = 3. (C) Dose-(24 h) and time-dependent [SAHA (2.5 μM), TSA (1 μM), or HDAC-42 (1 μM)] increases in 15-PGDH after treatment with HDACi. *P < 0.05 compared with DMSO (C) or 0 time point (D), ANOVA, Dunn's post hoc testing. n = 3. (E) Data represent fragments per kilobase of exon per million fragments mapped (FPKM) of class I, IIA, IIB, and IV HDACs expressed in hCSCs treated
with DMSO or PGE2 (100 nM) for 1 or 24 h mined from the RNA-seq dataset.
GAPDH and RPLP0 are shown as controls (1/100th FPKM values). *P < 0.05 compared with corresponding DMSO control.

Kishore, A. H., Liang, H., Kanchwala, M., Xing, C., Ganesh, T., Akgul, Y., ... & Word, R. A. (2017). Prostaglandin dehydrogenase is a target for successful induction of cervical ripening. Proceedings of the National Academy of Sciences, 114(31), E6427-E6436.

Figure 2 Western Blot Analysis of HDAC5 protein levels.

HDAC4 protein levels in hCSCs pretreated with DMSO or PF-04418948 (2 μM) followed by DMSO or PGE3. β-actin, loading control.

Figure 3 Masson’s trichrome stain of midcervical transverse sections of mice treated with (a) vehicle, (b) PGE2, (c) SW033291, or (d) PGE2 + SW033292.

Animals were treated bidaily on d 15 and d 16 with tissue collection on late d 16 before delivery. (Bar, 201 μm.) epi, epithelium; str, stroma.

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Mouse

Derivation
Mouse

Type
scFv

Specificity
Tested positive against native Indolicidin

Species Reactivity
Human

Clone
PGE2

Applications
Neut (assay dependent)
FuncS (assay dependent)

Product Property

Purity
>95% by SDS-PAGE and HPLC analysis

Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

Application Notes
Assay-depended

Target

Alternative Names
PGE2; Prostaglandin E2; PGE2; 2B5

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Breast cancer biomarkers at key points during disease progression

Effective scFv for Neutralization

This scFv fragment was exactly what we needed for our neutralization assays involving Prostaglandin E2. Its small size and specific binding allowed us to effectively block PGE2 activity in our cell-based models to study inflammation pathways.

Validated for Functional Studies

We used this product in functional studies to investigate osteoblast stimulation. The antibody performed reliably, showing positive results against the native antigen. The recombinant production ensures batch-to-batch consistency which is critical for our long-term projects.

Q&As

What is the format of this anti-PGE2 antibody?

A: This product is a Recombinant Mouse scFv (single-chain variable fragment) antibody. It is produced in E. coli and is designed to bind to Prostaglandin E2 (PGE2), offering a smaller size compared to full-length antibodies.
Can this antibody be used for neutralization assays?

A: Yes, this antibody has been tested for Neutralization (Neut) applications, as well as Functional Studies (FuncS). It can neutralize the bioactivity of PGE2 in assay-dependent contexts.

View the frequently asked questions answered by Creative Biolabs Support.

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Related Diseases

Rheumatoid Arthritis

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - PABX-160-S (P).pdf

MSDS

MSDS - PABX-160-S (P).pdf

COA

Certificate of Analysis Lookup

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