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Anti-PROM1 immunotoxin (scFv)-Sap (AGTO-G057S)

This immunotoxin was achieved by conjugating/fusing the Anti-PROM1 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to PROM1+ cells in localized primary tumors or metastasis and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of acute lymphocytic leukemia.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Molecule Class
scFv-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
acute lymphocytic leukemia
Target
Alternative Names
PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12
Entrez Gene ID
8842
UniProt ID
O43490

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "PROM1"
Recombinant Human Anti-PROM1 Antibody Fab Fragment (GC4)    ( HPAB-0088-FY-F(E) )
Recombinant Anti-Human PROM1 Antibody Fab Fragment    ( MOB-1990z-F(E) )
Anti-Mouse PROM1 Therapeutic Antibody Fab Fragment (SDIE W6B3)    ( TAB-0378CL-F(E) )
Recombinant Mouse Anti-PROM1 Antibody Fab Fragment (Mab7)    ( NS-019CN-F(E) )
Recombinant Anti-human PROM1 Intrabody [+36 GFP]    ( IAB-B028(G) )
Recombinant Human Anti-PROM1 Antibody scFv Fragment (GC4)    ( HPAB-0088-FY-S(P) )
Anti-Mouse PROM1 Therapeutic Antibody scFv Fragment (293AC1C3H9)    ( TAB-0375CL-S(P) )
Anti-Mouse PROM1 Therapeutic Antibody (SDIE W6B3)    ( TAB-0378CL )
>> MORE
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