Anti-PROM1 immunotoxin (scFv)-Sap (CAT#: AGTO-G057S)
This immunotoxin was achieved by conjugating/fusing the Anti-PROM1 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to PROM1+ cells in localized primary tumors or metastasis and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of acute lymphocytic leukemia.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Colon
(Goblet cells
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_8_3.jpg
(Goblet cells
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_8_3.jpg
Figure 2 Liver
(Cholangiocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_7_4.jpg
(Cholangiocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_7_4.jpg
Figure 3 Pancreas
(Exocrine glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_2_3.jpg
(Exocrine glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_2_3.jpg
Figure 4 Kidney
(Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Proximal tubules (cell body)
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_8_5.jpg
(Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Proximal tubules (cell body)
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4922/15212_A_8_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (AF22, CACO-2, CAPAN-2, EFO-21, NTERA-2, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007062-PROM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007062-PROM1
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- scFv-Sap
- Toxin Description
- Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- acute lymphocytic leukemia
Target
- Alternative Names
- PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen; saporin; saporin-6; saporin-S54; SAP
- Gene ID
- 8842
- UniProt ID
- O43490
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1990z | Mouse Anti-PROM1 Recombinant Antibody (clone 41D7) | WB, FC, IHC | Mouse IgG1 |
| HPAB-0183-YC | Human Anti-PROM1 Recombinant Antibody (clone h133H/h133La) | ELISA, FC | Humanized IgG |
| MRO-0275-CN | Recombinant Mouse Anti-PROM1 Monoclonal Antibody (D2-B1) | IHC, IF | Mouse IgG1 |
| HPAB-1396-FY | Human Anti-PROM1 Recombinant Antibody (clone H133) | FC | Humanized IgG |
| VS4-CJ93 | Recombinant Human Anti-PROM1 Antibody (clone 5F5) | ELISA | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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