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    Anti-Human RYK Recombinant Antibody Fab Fragment (RWD1) (CAT#: TAB-375CT-F(E))

    Recombinant monoclonal antibody specifically binds to the WIF domain of human RYK. This antibody modulates RYK-associated activity, which includes RYK mediated signal transduction activity and modulation of the interaction of Wnts with RYK and, preferably, modulates Wnt induced signaling. It inhibit the binding of Wnt5a and inhibit Wnt induced phosphorylation of Dishevelled (Dvl) 2 and/or Dvl3 proteins.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/75430/1614_E12_2_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human hippocampus
    Figure 2 IHC staining of human hippocampus
    (Immunohistochemical staining of human hippocampus shows strong nuclear positivity in glial cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/45503/ihc_selected.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_B_8_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_9_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_8_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_5_6.jpg
    Figure 7 Endometrium
    Figure 7 Endometrium
    (Cells in endometrial stroma Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_B_1_3.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_8_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Low cell line specificity
    Figure 9 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163785-RYK

    Specifications

    • Immunogen
    • H-RYK-FLAG protein
    • Host Species
    • Human
    • Derivation
    • Human phage display library
    • Type
    • Human antibody
    • Specificity
    • Human
    • Species Reactivity
    • Human
    • Clone
    • RWD1
    • Applications
    • Used for immunoassay techniques such as: Western Blot; Enzyme-linked Immunosorbent Assay; Blocking. Immunohistochemistry; Immunoprecipitation; Flow Cytometry
    • Related Disease
    • Lung, colon, prostate, breast, and skin cancer

    Target

    • Alternative Names
    • RYK; receptor-like tyrosine kinase; JTK5; RYK1; JTK5A; D3S3195; tyrosine-protein kinase RYK; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; anti-RYK

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    Please select product type
    Human Antibodies IgG Antibodies Rabbit Monoclonal Antibodies ScFv Antibodies Fab Antibodies Extracellular Vesicle Antibodies IHC Kits & Antibodies
    CAT Product Name Application Type
    TAB-375CT Anti-Human RYK Recombinant Antibody (RWD1) WB, IHC, ELISA Human antibody
    TAB-375CT-S(P) Anti-Human RYK Recombinant Antibody scFv Fragment (RWD1) WB, ELISA, BL. IHC, IP, FC Human antibody

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