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Mouse Anti-RYK Recombinant Antibody (VS3-CJ887) (CAT#: VS3-CJ887)

This product is a mouse antibody that recognizes human RYK.


See more Engineered Antibody products for RYK
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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75430/1614_E12_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human hippocampus
Figure 2 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows strong nuclear positivity in glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45503/ihc_selected.jpg
Figure 3 Cerebral cortex
Figure 3 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_B_8_5.jpg
Figure 4 Colon
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_9_3.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_5_6.jpg
Figure 7 Endometrium
Figure 7 Endometrium
(Cells in endometrial stroma Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_B_1_3.jpg
Figure 8 Lymph node
Figure 8 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34117/71467_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163785-RYK

Specifications

  • Immunogen
  • KLH-conjugated synthetic peptide between 260-565 amino acids from human RYK
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1, κ
  • Specificity
  • Human RYK
  • Species Reactivity
  • Human
  • Applications
  • WB, FC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • PBS
  • Preservative
  • 0.09% Sodium Azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot (1:1000), Flow Cytometry (1:25).

Target

  • Alternative Names
  • JTK5; RYK1; JTK5A; D3S3195
  • Sequence Similarities
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
  • Cellular Localization
  • Cytoplasm, Membrane, Nucleus
  • Post Translation Modifications
  • Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
  • Function
  • May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Recommended Products

Secondary Antibody

Recommended Dilution Buffer

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "RYK"

Human Antibody

CAT Product Name Application Type
TAB-375CT Anti-Human RYK Recombinant Antibody (RWD1) WB, IHC, ELISA Human antibody
TAB-375CT-S(P) Anti-Human RYK Recombinant Antibody scFv Fragment (RWD1) WB, ELISA, BL. IHC, IP, FC Human antibody
TAB-375CT-F(E) Anti-Human RYK Recombinant Antibody Fab Fragment (RWD1) WB, ELISA, BL. IHC, IP, FC Human antibody

Recombinant Antibody

CAT Product Name Application Type
MOB-2415CT Recombinant Mouse anti-Human RYK Monoclonal antibody (FQS4388) WB
HPAB-M0628-YC Mouse Anti-RYK Recombinant Antibody (HPAB-M0628-YC) Inhib Mouse IgG
HPAB-M0629-YC Mouse Anti-RYK Recombinant Antibody (HPAB-M0629-YC) Inhib Mouse IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3148 Hi-Affi™ Recombinant Rabbit Anti-RYK Monoclonal Antibody (DS3148AB) WB, IHC, ICC IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-M0628-YC-S(P) Mouse Anti-RYK Recombinant Antibody; scFv Fragment (HPAB-M0628-YC-S(P)) Inhib Mouse scFv
HPAB-M0629-YC-S(P) Mouse Anti-RYK Recombinant Antibody; scFv Fragment (HPAB-M0629-YC-S(P)) Inhib Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-M0628-YC-F(E) Mouse Anti-RYK Recombinant Antibody; Fab Fragment (HPAB-M0628-YC-F(E)) Inhib Mouse Fab
HPAB-M0629-YC-F(E) Mouse Anti-RYK Recombinant Antibody; Fab Fragment (HPAB-M0629-YC-F(E)) Inhib Mouse Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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