Recombinant Mouse Anti-SIGLEC9 Antibody (MM0552-6K12)
CAT#: NEUT-1964CQ
This antibody is a mouse monoclonal antibody that binds specifically to SIGLEC9, and it can neutralize the bioactivity of SIGLEC9.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human spleen
Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells in red pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10682/26903_B_8_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10682/26903_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10682/26903_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10682/26903_A_8_4.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10682/26903_A_6_6.jpg
Normal Tissue
Figure 6 Spleen
Cells in red pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10682/26903_B_8_4.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129450-SIGLEC9
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Specifications
- Immunogen
- Recombinant fragment of Human SIGLEC9 extracellular domain.
- Host Species
- Mouse
- Type
- IgG2
- Specificity
- Recognizes SIGLEC9
- Species Reactivity
- Human
- Clone
- MM0552-6K12
- Applications
- Used for immunoassay techniques such as: Western Blot; Neutralization
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze-thaw cycles.
Target
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Exceptional Specificity
The anti-SIGLEC9 antibody has significantly enhanced the precision of my immunofluorescence experiments. Its exceptional specificity allowed me to visualize SIGLEC9 localization within single cells accurately, without background interference. This precision was crucial for quantifying expression levels in heterogeneous cell populations. The reliable data obtained contributed to a deeper understanding of SIGLEC9's role in immune cell signaling, leading to a pivotal advancement in my research project.
Streamlined Workflow Efficiency
Incorporating this antibody into our protocols has greatly simplified our workflow. Its ease of use and consistent performance have reduced the time spent on troubleshooting and optimization. The simplified operation steps have allowed our team to focus more on data analysis and less on technical issues, improving overall laboratory efficiency and productivity.
Outstanding Technical Support
The supplier's technical support has been highly professional and responsive. Any inquiries we had were promptly addressed with in-depth knowledge and practical solutions. This level of service provided us with confidence and assurance, knowing that expert assistance was readily available whenever needed, which is a significant advantage in fast-paced research environments.
Q&As
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How does the anti-SIGLEC9 antibody facilitate research into the role of SIGLEC9 in cancer progression?
A: SIGLEC9 is known to modulate immune responses and has been implicated in tumor immune evasion mechanisms. The anti-SIGLEC9 antibody enables researchers to investigate the expression levels and functional status of SIGLEC9 in tumor cells and immune cells within the tumor microenvironment. By detecting SIGLEC9 expression patterns, the antibody helps elucidate how tumors may exploit SIGLEC9-mediated pathways to suppress immune surveillance. This understanding can lead to the development of new immunotherapeutic strategies targeting SIGLEC9 interactions in cancer treatment.
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What are the unique structural and functional characteristics of the SIGLEC9 epitope recognized by the anti-SIGLEC9 antibody, and how does this interaction influence protein networks?
A: The anti-SIGLEC9 antibody targets a specific extracellular epitope on SIGLEC9 characterized by a unique sequence and conformation critical for ligand binding. This precise targeting allows the antibody to bind without interfering with other siglec family members. The interaction can modulate SIGLEC9's role in cell signaling by blocking ligand engagement or altering receptor conformation. This affects downstream protein-protein interactions within signaling networks, potentially influencing processes like cell adhesion, migration, and immune response modulation.
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What stability characteristics does the antibody exhibit under various storage conditions and environmental factors?
A: The antibody exhibits excellent stability across a range of storage conditions, including prolonged periods at refrigeration and freezing temperatures. It maintains its functional integrity after multiple freeze-thaw cycles and remains effective even when stored at room temperature for short durations. Additionally, the antibody shows resilience to variations in humidity and pH levels, ensuring consistent performance in diverse laboratory environments. This stability reduces degradation risks and enhances the reproducibility of experimental results over time.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1963CQ | Recombinant Mouse Anti-SIGLEC9 Antibody (CBL273) | FC, ELISA, WB, Neut | IgG2a |
| NEUT-1965CQ | Recombinant Mouse Anti-SIGLEC9 Antibody (CBL164) | Neut, WB | IgG2 |
| NEUT-1966CQ | Recombinant Mouse Anti-SIGLEC9 Antibody (CBL711) | WB, FC, CyTOF, ELISA(Cap), Neut | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0648-YC | Mouse Anti-SIGLEC9 Recombinant Antibody (HPAB-M0648-YC) | FC, Cyt, Neut | Mouse IgG |
| HPAB-M0649-YC | Mouse Anti-SIGLEC9 Recombinant Antibody (HPAB-M0649-YC) | FC, Cyt, Neut | Mouse IgG |
| HPAB-M0650-YC | Mouse Anti-SIGLEC9 Recombinant Antibody (HPAB-M0650-YC) | FC, Cyt, Neut | Mouse IgG |
| HPAB-M0651-YC | Mouse Anti-SIGLEC9 Recombinant Antibody (HPAB-M0651-YC) | FC, Cyt | Mouse IgG |
| HPAB-3335LY | Human Anti-SIGLEC9 Recombinant Antibody (HPAB-3335LY) | FC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0648-YC-F(E) | Mouse Anti-SIGLEC9 Recombinant Antibody; Fab Fragment (HPAB-M0648-YC-F(E)) | FC, Cyt, Neut | Mouse Fab |
| HPAB-M0649-YC-F(E) | Mouse Anti-SIGLEC9 Recombinant Antibody; Fab Fragment (HPAB-M0649-YC-F(E)) | FC, Cyt, Neut | Mouse Fab |
| HPAB-M0650-YC-F(E) | Mouse Anti-SIGLEC9 Recombinant Antibody; Fab Fragment (HPAB-M0650-YC-F(E)) | FC, Cyt, Neut | Mouse Fab |
| HPAB-M0651-YC-F(E) | Mouse Anti-SIGLEC9 Recombinant Antibody; Fab Fragment (HPAB-M0651-YC-F(E)) | FC, Cyt | Mouse Fab |
| HPAB-3335LY-F(E) | Human Anti-SIGLEC9 Recombinant Antibody; Fab Fragment (HPAB-3335LY-F(E)) | FC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-3335LY-S(P) | Human Anti-SIGLEC9 Recombinant Antibody; scFv Fragment (HPAB-3335LY-S(P)) | FC | Humanized scfv |
| HPAB-3336LY-S(P) | Human Anti-SIGLEC9 Recombinant Antibody; scFv Fragment (HPAB-3336LY-S(P)) | FC | Humanized scfv |
| HPAB-3337LY-S(P) | Human Anti-SIGLEC9 Recombinant Antibody; scFv Fragment (HPAB-3337LY-S(P)) | FC | Humanized scfv |
| HPAB-3338LY-S(P) | Human Anti-SIGLEC9 Recombinant Antibody; scFv Fragment (HPAB-3338LY-S(P)) | FC | Humanized scfv |
| HPAB-3339LY-S(P) | Human Anti-SIGLEC9 Recombinant Antibody; scFv Fragment (HPAB-3339LY-S(P)) | FC | Humanized scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY479 | Mouse Anti-NHP SIGLEC9 Recombinant Antibody (clone OTI6D8) | WB, IHC, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC471 | Recombinant Anti-SIGLEC9 Vesicular Antibody, EV Displayed (VS-0425-YC471) | Cyt, ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6588 | Anti-SIGLEC9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6589 | Anti-Human SIGLEC9 Immunohistochemistry Kit | IHC |
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