Recombinant Mouse Anti-SIGLEC9 Antibody (MM0552-6K12) (CAT#: NEUT-1964CQ)

1. Q 1: How does the anti-SIGLEC9 antibody facilitate research into the role of SIGLEC9 in cancer progression?

   A: SIGLEC9 is known to modulate immune responses and has been implicated in tumor immune evasion mechanisms. The anti-SIGLEC9 antibody enables researchers to investigate the expression levels and functional status of SIGLEC9 in tumor cells and immune cells within the tumor microenvironment. By detecting SIGLEC9 expression patterns, the antibody helps elucidate how tumors may exploit SIGLEC9-mediated pathways to suppress immune surveillance. This understanding can lead to the development of new immunotherapeutic strategies targeting SIGLEC9 interactions in cancer treatment.

2. Q 2: What are the unique structural and functional characteristics of the SIGLEC9 epitope recognized by the anti-SIGLEC9 antibody, and how does this interaction influence protein networks?

   A: The anti-SIGLEC9 antibody targets a specific extracellular epitope on SIGLEC9 characterized by a unique sequence and conformation critical for ligand binding. This precise targeting allows the antibody to bind without interfering with other siglec family members. The interaction can modulate SIGLEC9's role in cell signaling by blocking ligand engagement or altering receptor conformation. This affects downstream protein-protein interactions within signaling networks, potentially influencing processes like cell adhesion, migration, and immune response modulation.

3. Q 3: What stability characteristics does the antibody exhibit under various storage conditions and environmental factors?

   A: The antibody exhibits excellent stability across a range of storage conditions, including prolonged periods at refrigeration and freezing temperatures. It maintains its functional integrity after multiple freeze-thaw cycles and remains effective even when stored at room temperature for short durations. Additionally, the antibody shows resilience to variations in humidity and pH levels, ensuring consistent performance in diverse laboratory environments. This stability reduces degradation risks and enhances the reproducibility of experimental results over time.

View the frequently asked questions answered by Creative Biolabs Support.