Afuco™ Anti-Human SLC40A1 ADCC Recombinant Antibody (LY2928057), ADCC Enhanced
CAT#: AFC-554CL
Anti-SLC40A1 ADCC Enhanced Antibody (LY2928057) is an ADCC enhanced antibody produced by our Afuco™ platform. LY2928057 is a novel humanized IgG4 monoclonal antibody that binds to human ferroportin with a high affinity, blocks the binding of human hepcidin to ferroportin, and is a potent inhibitor of hepcidin activity in a recombinant ferroportin expressing HEK 293 cell-based assay. LY2928057 may provide therapeutic benefit for patients with hepcidin-related anemia by stabilizing ferroportin located on the cell surface, thus restoring iron export and erythropoiesis. LY2928057 is currently in clinical evaluation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/1249_G12_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows strong positivity in liver sinusoids.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/155954_A_9_4_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/155954_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/155954_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, CACO-2, HEL, HMC-1, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138449-SLC40A1
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Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Anemia
Product Property
- Purity
- >98% by SDS-PAGE and HPLC analysis
- Storage
- Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Target
- Alternative Names
- SLC40A1; solute carrier family 40 (iron-regulated transporter), member 1; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3; solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
- Gene ID
- 30061
- UniProt ID
- Q9NP59
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-576CL | Human Anti-SLC40A1 Recombinant Antibody (TAB-576CL) | ELISA | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-044WM | Mouse Anti-SLC40A1 Recombinant Antibody (TAB-044WM) | IF, WB, ELISA, IHC | Mouse IgG |
| TAB-044WM-S(P) | Mouse Anti-SLC40A1 Recombinant Antibody; scFv Fragment (TAB-044WM-S(P)) | ELISA, IHC, WB | Mouse scFv |
| TAB-044WM-F(E) | Mouse Anti-SLC40A1 Recombinant Antibody; Fab Fragment (TAB-044WM-F(E)) | ELISA, IHC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-045WM | Human Anti-SLC40A1 Recombinant Antibody (TAB-045WM) | ELISA, WB | Human IgG |
| TAB-045WM-S(P) | Human Anti-SLC40A1 Recombinant Antibody; scFv Fragment (TAB-045WM-S(P)) | ELISA, WB | Human scFv |
| TAB-045WM-F(E) | Human Anti-SLC40A1 Recombinant Antibody; Fab Fragment (TAB-045WM-F(E)) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-CN | Mouse Anti-SLC40A1 Recombinant Antibody (clone 34A9) | ELISA | Mouse IgG |
| HPAB-0752-CN | Human Anti-SLC40A1 Recombinant Antibody (clone 4A10-3) | ELISA | Humanized IgG4 |
| HPAB-0753-CN | Human Anti-SLC40A1 Recombinant Antibody (clone L2.2-4) | ELISA | Humanized IgG4 |
| HPAB-0754-CN | Human Anti-SLC40A1 Recombinant Antibody (clone Com11GY) | ELISA | Humanized IgG4 |
| HPAB-AP801-YC | Human Anti-SLC40A1 Recombinant Antibody (clone 3D8) | Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-CN-S(P) | Mouse Anti-SLC40A1 Recombinant Antibody (clone 34A9); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0752-CN-S(P) | Human Anti-SLC40A1 Recombinant Antibody (clone 4A10-3); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0753-CN-S(P) | Human Anti-SLC40A1 Recombinant Antibody (clone L2.2-4); scFv Fragment | ELISA | Humanized scFv |
| HPAB-AP801-YC-S(P) | Human Anti-SLC40A1 Recombinant Antibody (clone 3D8); scFv Fragment | Inhib | Human scFv |
| HPAB-AP802-YC-S(P) | Human Anti-SLC40A1 Recombinant Antibody; scFv Fragment (HPAB-AP802-YC-S(P)) | ELISA, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-CN-F(E) | Mouse Anti-SLC40A1 Recombinant Antibody (clone 34A9); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0752-CN-F(E) | Human Anti-SLC40A1 Recombinant Antibody (clone 4A10-3); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0753-CN-F(E) | Human Anti-SLC40A1 Recombinant Antibody (clone L2.2-4); Fab Fragment | ELISA | Humanized Fab |
| HPAB-AP801-YC-F(E) | Human Anti-SLC40A1 Recombinant Antibody (clone 3D8); Fab Fragment | Inhib | Human Fab |
| HPAB-AP802-YC-F(E) | Human Anti-SLC40A1 Recombinant Antibody; Fab Fragment (HPAB-AP802-YC-F(E)) | ELISA, Inhib, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC335 | Recombinant Anti-SLC40A1 Vesicular Antibody, EV Displayed (VS-0425-YC335) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6683 | Anti-SLC40A1 Immunohistochemistry Kit | IHC |
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