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SLC40A1

SLC40A1 is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).
Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Syncytiotrophoblasts, Kupffer cells, Cytotrophoblasts)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (ASC diff, CACO-2, HEL, HMC-1, T-47d)

Interaction

Identified in a complex with STOM (PubMed:23219802). Interacts with HAMP; this interaction promotes SLC40A1 rapid ubiquitination (PubMed:22682227, PubMed:29237594).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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