Anti-TAG72 Antibody-Cytokine Fusion Protein, scFv (cc49)-FasL
CAT#: ACFP-SH018
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAG72 scFv to FasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAG72 as well as the biological activity of FasL. This antibody-cytokine fusion protein is highly effective in in vitro killing of human TAG-72+ Jurkat-Ras tumor cells with a 30,000 fold greater cytotoxicity as compared to soluble FasL (sFasL). ScFv-FasLext with a strong cytotoxicity against sensitive human tumor targets may be useful as effective chemotherapeutic agents. This immunocytokine was designed for treating human Jurkat-Ras cancer.
Specifications
- Target
- TAG72
- Molecule Class
- scFv-FasL
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- cc49
- Related Disease
- human Jurkat-Ras cancer
- Cytokine 1
- FasL
- Cytokines 1 Description
- Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- CA 72.4; TAG 72; Tumor associated Glycoprotein 72; TAG72
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Datasheet
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See other products for "Clone cc49"
- CAT
- Product Name
See other products for "TAG72"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-723 | Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, WB | Mouse Fab (IgG1, κ) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H60 | Anti-Human TAG-72 Recombinant Antibody (Satumomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-249 | Anti-Human TAG-72 Recombinant Antibody (Minretumomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-002 | Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) | IP, IF, FuncS, FC, Neut, ELISA, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L070E | anti-TAG72 immunotoxin CC49 (scFv)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2) | WB, ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2); Fab Fragment | WB, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2); scFv Fragment | WB, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0285CL | Human Anti-TAG72 Recombinant Antibody (TAB-0285CL) | DB, IHC, BI, SPR | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0286CL | Human Anti-TAG72 Recombinant Antibody (TAB-0286CL) | DB, IHC, BI, SPR | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0285CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0285CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0286CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0286CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0285CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0285CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-505CT | Humanized Anti-TAG72 Recombinant Antibody (TAB-505CT) | WB, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-505CT-S(P) | Humanized Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-505CT-S(P)) | WB, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-505CT-F(E) | Humanized Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-505CT-F(E)) | WB, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-016LC | Recombinant Anti-Human TAG-72 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-025 | Recombinant Human Anti-TAG-72 Antibody (PABX-025) | WB, Neut, FuncS, ELISA, Cyt | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-025-S (P) | Recombinant Human Anti-TAG-72 Antibody scFv Fragment (PABX-025-S (P)) | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-025-F (E) | Recombinant Human Anti-TAG-72 Antibody Fab Fragment (PABX-025-F (E)) | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0278YC | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49) | FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0279YC | Human Anti-TAG72 Recombinant Antibody (clone cCC49) | FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0280YC | Human Anti-TAG72 Recombinant Antibody (clone HuCC49) | FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0278-YC-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49); scFv Fragment | FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0279-YC-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone cCC49); scFv Fragment | FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0280-YC-S(P) | Human Anti-TAG72 Recombinant Antibody (clone HuCC49); scFv Fragment | FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0278-YC-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49); Fab Fragment | FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0279-YC-F(E) | Human Anti-TAG72 Recombinant Antibody (clone cCC49); Fab Fragment | FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0280-YC-F(E) | Human Anti-TAG72 Recombinant Antibody (clone HuCC49); Fab Fragment | FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0315CQ | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19) | IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0315CQ-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0315CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0123-CN | Mouse Anti-TAG72 Recombinant Antibody (clone TKH6) | WB, ELISA | Mouse IgM, Κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-249 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-249) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H60 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H60) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY87 | Human Anti-TAG72 (clone hum4) scFv-Fc Chimera | ELISA, Inhib, SPR, ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY190 | Mouse Anti-TAG-72 (clone Satumomab) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
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