Anti-TAG72 Antibody-Cytokine Fusion Protein, scFv (cc49)-FasL
CAT#: ACFP-SH018
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAG72 scFv to FasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAG72 as well as the biological activity of FasL. This antibody-cytokine fusion protein is highly effective in in vitro killing of human TAG-72+ Jurkat-Ras tumor cells with a 30,000 fold greater cytotoxicity as compared to soluble FasL (sFasL). ScFv-FasLext with a strong cytotoxicity against sensitive human tumor targets may be useful as effective chemotherapeutic agents. This immunocytokine was designed for treating human Jurkat-Ras cancer.
Specifications
- Target
- TAG72
- Molecule Class
- scFv-FasL
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- cc49
- Related Disease
- human Jurkat-Ras cancer
- Cytokine 1
- FasL
- Cytokines 1 Description
- Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- CA 72.4; TAG 72; Tumor associated Glycoprotein 72; TAG72
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See other products for "Clone CC49"
- CAT
- Product Name
See other products for "TAG72"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-723 | Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, WB | Mouse Fab (IgG1, κ) |
| TAB-H60 | Anti-Human TAG-72 Recombinant Antibody (Satumomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-249 | Anti-Human TAG-72 Recombinant Antibody (Minretumomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-002 | Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) | IP, IF, FuncS, FC, Neut, ELISA, WB | IgG1 |
| PABX-025-S (P) | Recombinant Human Anti-TAG-72 Antibody scFv Fragment (PABX-025-S (P)) | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L070E | anti-TAG72 immunotoxin CC49 (scFv)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2) | WB, ELISA | Humanized IgG |
| FAMAB-0119-CN | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3) | WB, ELISA | Mouse IgG |
| FAMAB-0120-CN | Human Anti-TAG72 Recombinant Antibody (clone ccM4) | WB, ELISA | Chimeric (mouse/human) IgG1, Κ |
| FAMAB-0121-CN | Human Anti-TAG72 Recombinant Antibody (clone hmM4) | WB, ELISA | Humanized IgG1 |
| FAMAB-0122-CN | Human Anti-TAG72 Recombinant Antibody (clone FV/M4) | WB, ELISA | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0285CL | Human Anti-TAG72 Recombinant Antibody (TAB-0285CL) | DB, IHC, BI, SPR | Human IgG |
| TAB-0285CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0285CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| TAB-0286CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0286CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| TAB-0285CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0285CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
| TAB-0286CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0286CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-505CT | Humanized Anti-TAG72 Recombinant Antibody (TAB-505CT) | WB, ELISA | Humanized antibody |
| TAB-505CT-S(P) | Humanized Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-505CT-S(P)) | WB, ELISA | Humanized scFv |
| TAB-505CT-F(E) | Humanized Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-505CT-F(E)) | WB, ELISA | Humanized Fab |
| PABX-025 | Recombinant Human Anti-TAG-72 Antibody (PABX-025) | WB, Neut, FuncS, ELISA, Cyt | IgG |
| PABX-025-F (E) | Recombinant Human Anti-TAG-72 Antibody Fab Fragment (PABX-025-F (E)) | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-016LC | Recombinant Anti-Human TAG-72 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0278-YC-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49); Fab Fragment | FuncS | Mouse Fab |
| FAMAB-0279-YC-F(E) | Human Anti-TAG72 Recombinant Antibody (clone cCC49); Fab Fragment | FuncS | Human Fab |
| FAMAB-0280-YC-F(E) | Human Anti-TAG72 Recombinant Antibody (clone HuCC49); Fab Fragment | FuncS | Humanized Fab |
| FAMAB-0315CQ-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0316CQ-F(E) | Human Anti-TAG72 Recombinant Antibody (clone cACT19); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0123-CN | Mouse Anti-TAG72 Recombinant Antibody (clone TKH6) | WB, ELISA | Mouse IgM, Κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0119-CN-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3); scFv Fragment | WB, ELISA | Mouse scFv |
| FAMAB-0120-CN-S(P) | Human Anti-TAG72 Recombinant Antibody (clone ccM4); scFv Fragment | WB, ELISA | Human scFv |
| FAMAB-0121-CN-S(P) | Human Anti-TAG72 Recombinant Antibody (clone hmM4); scFv Fragment | WB, ELISA | Human scFv |
| FAMAB-0122-CN-S(P) | Human Anti-TAG72 Recombinant Antibody (clone FV/M4); scFv Fragment | WB, ELISA | Human scFv |
| FAMAB-0123-CN-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone TKH6); scFv Fragment | WB, ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-249 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-249) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-H60 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H60) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY87 | Human Anti-TAG72 (clone hum4) scFv-Fc Chimera | ELISA, Inhib, SPR, ADCC | Human IgG1, scFv-Fc |
| VS-0425-FY190 | Mouse Anti-TAG-72 (clone Satumomab) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
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