anti-TAG72 immunotoxin CC49 (scFv)-PE
CAT#: AGTO-L070E
This immunotoxin was achieved by conjugating/fusing the Anti-TAG72 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Colon carcinoma cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Colon carcinoma.
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- CC49
- Molecule Class
- scFv-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Colon carcinoma
Target
- Alternative Names
- CA 72.4; TAG 72; Tumor associated Glycoprotein 72 antibody; Colon carcinoma; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for AGTO-L070E. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone cc49"
- CAT
- Product Name
See other products for "TAG72"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-723 | Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, WB | Mouse Fab (IgG1, κ) |
| TAB-H60 | Anti-Human TAG-72 Recombinant Antibody (Satumomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-249 | Anti-Human TAG-72 Recombinant Antibody (Minretumomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-002 | Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) | IP, IF, FuncS, FC, Neut, ELISA, WB | IgG1 |
| PABX-025-S (P) | Recombinant Human Anti-TAG-72 Antibody scFv Fragment (PABX-025-S (P)) | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2); Fab Fragment | WB, ELISA | Humanized Fab |
| FAMAB-0119-CN-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3); Fab Fragment | WB, ELISA | Mouse Fab |
| FAMAB-0120-CN-F(E) | Human Anti-TAG72 Recombinant Antibody (clone ccM4); Fab Fragment | WB, ELISA | Human Fab |
| FAMAB-0121-CN-F(E) | Human Anti-TAG72 Recombinant Antibody (clone hmM4); Fab Fragment | WB, ELISA | Human Fab |
| FAMAB-0122-CN-F(E) | Human Anti-TAG72 Recombinant Antibody (clone FV/M4); Fab Fragment | WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0285CL | Human Anti-TAG72 Recombinant Antibody (TAB-0285CL) | DB, IHC, BI, SPR | Human IgG |
| TAB-0286CL | Human Anti-TAG72 Recombinant Antibody (TAB-0286CL) | DB, IHC, BI, SPR | Human IgG |
| TAB-0285CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0285CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| TAB-0286CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0286CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
| TAB-0285CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0285CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-505CT | Humanized Anti-TAG72 Recombinant Antibody (TAB-505CT) | WB, ELISA | Humanized antibody |
| TAB-505CT-S(P) | Humanized Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-505CT-S(P)) | WB, ELISA | Humanized scFv |
| TAB-505CT-F(E) | Humanized Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-505CT-F(E)) | WB, ELISA | Humanized Fab |
| PABX-025 | Recombinant Human Anti-TAG-72 Antibody (PABX-025) | WB, Neut, FuncS, ELISA, Cyt | IgG |
| PABX-025-F (E) | Recombinant Human Anti-TAG-72 Antibody Fab Fragment (PABX-025-F (E)) | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-016LC | Recombinant Anti-Human TAG-72 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0278YC | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49) | FuncS | Mouse IgG |
| FAMAB-0315CQ | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19) | IHC | Mouse IgG1, κ |
| FAMAB-0316CQ | Human Anti-TAG72 Recombinant Antibody (clone cACT19) | ELISA | Chimeric (mouse/human) IgG1, κ |
| FAMAB-0317CQ | Mouse Anti-TAG72 Recombinant Antibody (clone CC49) | WB, IP, IF, IHC, FC | Mouse IgG1, κ |
| HPAB-A1328-YJ | Human Anti-TAG-72 Recombinant Antibody (clone hum4) | ELISA, Inhib, and SPR | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0315CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0317CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone CC49); scFv Fragment | WB, IP, IF, IHC, FC | Mouse scFv |
| FAMAB-0119-CN-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3); scFv Fragment | WB, ELISA | Mouse scFv |
| FAMAB-0120-CN-S(P) | Human Anti-TAG72 Recombinant Antibody (clone ccM4); scFv Fragment | WB, ELISA | Human scFv |
| FAMAB-0121-CN-S(P) | Human Anti-TAG72 Recombinant Antibody (clone hmM4); scFv Fragment | WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0123-CN | Mouse Anti-TAG72 Recombinant Antibody (clone TKH6) | WB, ELISA | Mouse IgM, Κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-249 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-249) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-H60 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H60) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY87 | Human Anti-TAG72 (clone hum4) scFv-Fc Chimera | ELISA, Inhib, SPR, ADCC | Human IgG1, scFv-Fc |
| VS-0425-FY190 | Mouse Anti-TAG-72 (clone Satumomab) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application: WB, ELISA, FuncS
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, WB, Inhib, IHC
Application: Inhib, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
