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anti-TAG72 immunotoxin CC49 (scFv)-PE (AGTO-L070E)

This immunotoxin was achieved by conjugating/fusing the Anti-TAG72 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Colon carcinoma cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Colon carcinoma.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
CC49
Molecule Class
scFv-PE
Toxin Description
Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Colon carcinoma
Target
Alternative Names
CA 72.4; TAG 72; Tumor associated Glycoprotein 72 antibody; Colon carcinoma; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "TAG72"
Recombinant Human Anti-TAG72 Antibody Fab Fragment (cCC49)    ( FAMAB-0279-YC-F(E) )
Anti-Human TAG72 Therapeutic Antibody (OncoScint CR103)    ( TAB-002 )
Recombinant Chimeric (mouse/human) Anti-TAG72 Antibody (FV/M4)    ( FAMAB-0122-CN )
Recombinant Mouse Anti-TAG72 Antibody Fab Fragment (TKH6)    ( FAMAB-0123-CN-F(E) )
Anti-Human TAG-72 Therapeutic Antibody (ONCOSCINT)    ( TAB-H60 )
Anti-Human TAG-72 Therapeutic Antibody Fab Fragment (3E8.scFv.Cys)    ( TAB-0286CL-F(E) )
Recombinant Human Anti-TAG-72 Antibody scFv Fragment (B72.3)    ( PABX-025-S (P) )
Recombinant Humanized Anti-TAG-72 Antibody (HuCC49DeltaCH2)    ( PABW-119 )
>> MORE
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