anti-THY1 immunotoxin AT15E (IgG)-RTA (CAT#: AGTO-L040R)
This immunotoxin was achieved by conjugating/fusing the Anti-THY1 monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to central noradrenergic neurons cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Lipidosis.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3733/992_A2_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3733/992_A2_2_selected.jpg
Figure 2 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows moderate membranous positivity in cells in tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68243/ihc_selected.jpg
(Immunohistochemical staining of human kidney shows moderate membranous positivity in cells in tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68243/ihc_selected.jpg
Figure 3 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows moderate nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68244/ihc_selected.jpg
(Immunohistochemical staining of human hippocampus shows moderate nuclear positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68244/ihc_selected.jpg
Figure 4 Cerebral cortex
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3733/156319_B_8_5.jpg
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3733/156319_B_8_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, BJ, BJ hTERT+, fHDF/TERT166)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154096-THY1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000154096-THY1
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- AT15E
- Molecule Class
- IgG2c-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Lipidosis
Target
- Alternative Names
- THY1; Thy-1 cell surface antigen; CD90; thy-1 membrane glycoprotein; CDw90; thy-1 antigen; Thy-1 T-cell antigen; Lipidosis; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 7070
- UniProt ID
- B0YJA4
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1495z-F(E) | Recombinant Anti-Human THY1 Antibody Fab Fragment | FC, WB, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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