This immunotoxin was achieved by conjugating/fusing the Anti-Thy1 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neurons cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Lipidosis.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1495z-F(E) | Recombinant Anti-Human THY1 Antibody Fab Fragment | FC, WB, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G060R | Anti-THY1 immunotoxin OX7 (F (ab')2)-RTA | Cytotoxicity assay, Function study | |
AGTO-G060S | Anti-THY1 immunotoxin OX7 (F (ab')2)-Sap | Cytotoxicity assay, Function study | |
AGTO-L040R | anti-THY1 immunotoxin AT15E (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L040S | anti-THY1 immunotoxin AT15E (IgG)-Sap | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2023CQ | Rat Anti-THY1 Recombinant Antibody (clone YKIX337.217) | Block, FC | Rat IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3568 | Rabbit Anti-THY1 Recombinant Antibody (clone DS3568AB) | ICC, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FN-266CQ | Rat Anti-Thy1 Recombinant Antibody (clone M5/49.4.1) | Depletion | Rat IgG2a, κ |
FAMAB-1502CQ | Rabbit Anti-THY1 Recombinant Antibody (clone YKIX 337.217) | Depletion, IP, FC | Rabbit IgG |
FAMAB-1504CQ | Mouse Anti-THY1 Recombinant Antibody (clone YBM 29.2.1) | IHC | Mouse IgG2a |
VS3-CJ336 | Mouse Anti-THY1 Recombinant Antibody (clone 5E10) | IF, FC | Mouse IgG1, κ |
VS3-CJ337 | Rabbit Anti-THY1 Recombinant Antibody (VS3-CJ337) | WB, IHC, ICC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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