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anti-THY1 immunotoxin AT15E (IgG)-Sap (AGTO-L040S)

This immunotoxin was achieved by conjugating/fusing the Anti-THY1 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to central noradrenergic neurons cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Lipidosis.      

  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
AT15E
Molecule Class
IgG2c-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Lipidosis
Target
Alternative Names
THY1; Thy-1 cell surface antigen; CD90; thy-1 membrane glycoprotein; CDw90; thy-1 antigen; Thy-1 T-cell antigen; Lipidosis
Entrez Gene ID
7070
UniProt ID
B0YJA4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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