Afuco™ Anti-Human TNFRSF4 ADCC Recombinant Antibody (MEDI6469), ADCC Enhanced

Name: Afuco™ Anti-Human TNFRSF4 ADCC Recombinant Antibody (MEDI6469), ADCC Enhanced
SKU: AFC-609CL
Rating: 5 (1 reviews)

CAT#: AFC-609CL

Anti-TNFRSF4 ADCC Enhanced Antibody (MEDI6469) is an ADCC enhanced antibody produced by our Afuco™ platform. MEDI6469 is a murine (mouse)-based antibody that binds to and activates a protein in humans called OX40. Because OX40 helps activate the immune system, it is hoped that it will encourage the immune system to recognize and eliminate cancer cells.

Gene Expression

Normal Tissue Figure 1 High expression in lymph node.

Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16128/35587_A_7_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16128/35587_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Group enriched (MOLT-4, NB-4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186827-TNFRSF4

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Specifications

Host Species
Mouse

Derivation
Mouse

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
FuncS

Related Disease
Cancer; Melanoma

Product Property

Purity
>97%, by SDS-PAGE under reducing conditions

Storage
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

Application Notes
The antibody was validated for Function Assay. For details, refer to Published Data.

Target

Alternative Names
TNFRSF4; tumor necrosis factor receptor superfamily, member 4; OX40; ACT35; CD134; IMD16; TXGP1L; tumor necrosis factor receptor superfamily member 4; OX40 antigen; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 homologue; OX40L receptor; OX40 cell surface antigen; lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor

Gene ID
7293

UniProt ID
P43489

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-609CL.pdf

MSDS

MSDS - AFC-609CL.pdf

COA

Certificate of Analysis Lookup

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