The anti-OX40L antibody specifically bind to human OX40L of which a domain containing an asparagine residue located at position-90. By binding to the OX40L and preventing the adhesion of influenza viruses onto the surfaces of cell, the specific antibody can be used for the treatment of influenza.
Figure 1 The mutation of human OX40L at 90 asparagine attenuates the binding affinity only for the clone W66 among anti-human OX40L monoclonal antibodies examined.
MDCK cells were transfected with the wild‐type human OX40L gene (gray) or the 90 asparagine mutant (red, 90Asn→Ala) and were stained with monoclonal antibody W66. The mean fluorescent intensity was measured by flow cytometry.
Hirano, T., Kikuchi, T., Tode, N., Santoso, A., Yamada, M., Mitsuhashi, Y., ... & Tanaka, Y. (2016). OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. EMBO molecular medicine, 8(4), 422-436.
Figure 2 Human OX40L mediates influenza infection in vitro.
The transfected MDCK cells were stained with W66 anti-human OX40L antibody, and the MFI was measured by flow cytometry.
Hirano, T., Kikuchi, T., Tode, N., Santoso, A., Yamada, M., Mitsuhashi, Y., ... & Tanaka, Y. (2016). OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. EMBO molecular medicine, 8(4), 422-436.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
NABL-102 | Recombinant Anti-human TNFSF4 VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
HPAB-0617-CN | Llama Anti-TNFSF4 Recombinant Single Domain Antibody (HPAB-0617-CN) | ELISA, FC, Block | Llama VHH |
HPAB-0618-CN | Llama Anti-TNFSF4 Recombinant Single Domain Antibody (HPAB-0618-CN) | ELISA, FC, Block | Llama VHH |
There are currently no Customer reviews or questions for TAB-0270CL. Click the button above to contact us or submit your feedback about this product.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.