Anti-Human Tau Recombinant Antibody (pT231/pS235_1) (CAT#: TAB-530CT)
Recombinant monoclonal antibody specifically binds to phospho-tau with high affinity. This antibody can be potentially used in treating Alzheimer's Disease.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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WB
Figure 1 Expression and binding activity of chimeric IgG molecules converted from scFv.
Western blot analysis of chimeric IgG molecules convertedfrom scFv clones pT231/pS235_1, pS396/pS404_1, and pT212/pS214_1, respectively. The heavy and light chains for each IgG are indicated by arrows.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
ELISA
Figure 2 Expression and binding activity of chimeric IgG molecules converted from scFv.
ELISA analysis of each purified IgG molecule for binding to the phosphopeptide, non-phosphopeptide, and scrambled (Scr) peptide.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
IHC
Figure 3 Binding of pathological phospho-tau by antibody pT231/pS235_1 in human AD and Tg4510 transgenic mouse brains.
Immunohisto-chemical staining of human AD brain (Aand B) and healthy brain.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
WB
Figure 4 Western blot analysis of Tg4510 transgenic andwild-type brain lysates with pT231/pS235_1 IgG (plus control anti-GAPDH antibody).
Each lane represents a different animal, and the lysate samples are3-month-old wild-type mice (lanes 1 and 2), 3-month-old transgenic mice (lanes 3 and 4), 6-month-old wild-type mice (lanes 5 and 6), and 6-month-oldtransgenic mice (lanes 7 and 8).
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
Specifications
- Host Species
- Chicken
- Derivation
- Phage display library
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- pT231/pS235_1
- Applications
- WB, ELISA, IHC
- Related Disease
- Alzheimer's Disease
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Immunohistochemistry and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-951-S(P) | Recombinant Anti-Tau Antibody scFv Fragment | FC, Neut, Funcs | scFv |
| HPAB-2561LY-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (HPAB-2561LY-S(P)) | WB, IHC, ELISA | Human scFv |
| HPAB-2562LY-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (HPAB-2562LY-S(P)) | WB, IHC, ELISA | Human scFv |
| HPAB-S0178-YC-S(P) | Mouse Anti-Tau Recombinant Antibody (clone Tau5); scFv Fragment | ELISA | Mouse scFv |
| MOB-0054SW-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (MOB-0054SW-S(P)) | ELISA, FuncS | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
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