Recombinant monoclonal antibody specifically binds to phospho-tau with high affinity. This antibody can be potentially used in treating Alzheimer's Disease.
Figure 1 Expression and binding activity of chimeric IgG molecules converted from scFv.
Western blot analysis of chimeric IgG molecules convertedfrom scFv clones pT231/pS235_1, pS396/pS404_1, and pT212/pS214_1, respectively. The heavy and light chains for each IgG are indicated by arrows.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
Figure 2 Expression and binding activity of chimeric IgG molecules converted from scFv.
ELISA analysis of each purified IgG molecule for binding to the phosphopeptide, non-phosphopeptide, and scrambled (Scr) peptide.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
Figure 3 Binding of pathological phospho-tau by antibody pT231/pS235_1 in human AD and Tg4510 transgenic mouse brains.
Immunohisto-chemical staining of human AD brain (Aand B) and healthy brain.
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
Figure 4 Western blot analysis of Tg4510 transgenic andwild-type brain lysates with pT231/pS235_1 IgG (plus control anti-GAPDH antibody).
Each lane represents a different animal, and the lysate samples are3-month-old wild-type mice (lanes 1 and 2), 3-month-old transgenic mice (lanes 3 and 4), 6-month-old wild-type mice (lanes 5 and 6), and 6-month-oldtransgenic mice (lanes 7 and 8).
Shih, H. H., Tu, C., Cao, W., Klein, A., Ramsey, R., Fennell, B. J., ... & Laxmanan, S. (2012). An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition. Journal of Biological Chemistry, 287(53), 44425-44434.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-951 | Recombinant Anti-Tau Antibody | ELISA, WB, IP, FuncS | IgG |
MHH-951 | Recombinant Human Anti-Tau Antibody | WB, Neut, FuncS | IgG |
HPAB-S0178-YC | Mouse Anti-Tau Recombinant Antibody (clone Tau5) | ELISA | Mouse IgG |
MOB-0054SW | Human Anti-Tau Recombinant Antibody (MOB-0054SW) | ELISA, FuncS | Humanized IgG4 |
PABS-0209 | Mouse Anti-Tau Recombinant Antibody (clone C5.2) | ELISA, WB, DB, IHC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-951-S(P) | Recombinant Anti-Tau Antibody scFv Fragment | FC, Neut, Funcs | scFv |
HPAB-2570LY-S(P) | Mouse Anti-Tau Recombinant Antibody; scFv Fragment (HPAB-2570LY-S(P)) | IP, WB | Mouse scFv |
HPAB-S0178-YC-S(P) | Mouse Anti-Tau Recombinant Antibody (clone Tau5); scFv Fragment | ELISA | Mouse scFv |
MOB-0054SW-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (MOB-0054SW-S(P)) | ELISA, FuncS | Humanized scFv |
FAMAB-0352WJ-S(P) | Mouse Anti-Tau Recombinant Antibody (clone MHT2); scFv Fragment | ELISA, WB, IHC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0427CL | Human Anti-Tau Recombinant Antibody (TAB-0427CL) | ELISA, WB, IHC, FuncS | Human IgG |
TAB-0428CL | Human Anti-Tau Recombinant Antibody (TAB-0428CL) | ELISA, WB | Human IgG |
TAB-0429CL | Human Anti-Tau Recombinant Antibody (TAB-0429CL) | ELISA, WB | Human IgG |
TAB-0427CL-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (TAB-0427CL-S(P)) | ELISA, WB, IHC, FuncS | Human scFv |
TAB-0428CL-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (TAB-0428CL-S(P)) | ELISA, WB | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-527CT | Human Anti-Tau Recombinant Antibody (TAB-527CT) | IF, FuncS | Humanized antibody |
TAB-527CT-S(P) | Human Anti-Tau Recombinant Antibody; scFv Fragment (TAB-527CT-S(P)) | WB, ELISA, IHC | Human scFv |
TAB-533CT-S(P) | Humanized Anti-Tau Recombinant Antibody; scFv Fragment (TAB-533CT-S(P)) | WB, ELISA, IP, IHC, Neut | Humanized scFv |
TAB-527CT-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (TAB-527CT-F(E)) | WB, ELISA, IHC | Humanized Fab |
TAB-533CT-F(E) | Humanized Anti-Tau Recombinant Antibody; Fab Fragment (TAB-533CT-F(E)) | WB, ELISA, IP, IHC, Neut | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-519CT-S(P) | Mouse Anti-Tau Recombinant Antibody; scFv Fragment (TAB-519CT-S(P)) | WB, ELISA | Mouse scFv |
TAB-520CT-S(P) | Mouse Anti-Tau Recombinant Antibody; scFv Fragment (TAB-520CT-S(P)) | WB, ELISA | Mouse scFv |
TAB-521CT-S(P) | Mouse Anti-Tau Recombinant Antibody; scFv Fragment (TAB-521CT-S(P)) | WB, ELISA | Mouse scFv |
TAB-522CT-S(P) | Mouse Anti-Tau Recombinant Antibody; scFv Fragment (TAB-522CT-S(P)) | WB, ELISA | Mouse scFv |
TAB-523CT-S(P) | Mouse Anti-Tau Recombinant Antibody; scFv Fragment (TAB-523CT-S(P)) | WB, ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2561LY-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (HPAB-2561LY-F(E)) | WB, IHC, ELISA | Humanized Fab |
HPAB-2562LY-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (HPAB-2562LY-F(E)) | WB, IHC, ELISA | Humanized Fab |
HPAB-2563LY-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (HPAB-2563LY-F(E)) | WB, IHC, ELISA | Humanized Fab |
HPAB-2564LY-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (HPAB-2564LY-F(E)) | WB | Humanized Fab |
HPAB-2565LY-F(E) | Human Anti-Tau Recombinant Antibody; Fab Fragment (HPAB-2565LY-F(E)) | WB | Humanized Fab |
There are currently no Customer reviews or questions for TAB-530CT. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.