Anti-Human oxLDL Recombinant Antibody (2-DO3) (CAT#: TAB-0904CL)

Figure 1 Immunohistochemical staining of consecutive sections of aortic plaques from mice injected with 2D03 antibody.

Staining in vitro with additional 2D03 antibody to visualize the total available 2D03 epitopes.

Örbom, A., Jansson, B., Schiopu, A., Evans-Axelsson, S., Nilsson, J., Fredrikson, G. N., & Strand, S. E. (2014). Multi-radionuclide digital autoradiography of the intra-aortic atherosclerotic plaques using a monoclonal antibody targeting oxidized low-density lipoprotein. American journal of nuclear medicine and molecular imaging, 4(2), 172.

Figure 2 Flow cytometry histogram showing ABCA-1 expression in different cell lines.

Untreated (gray shaded peak), FITC-8 –treated (black line overlay), and 2D03-treated (red line overlay) cells.

Schiopu, A., Frendéus, B., Jansson, B., Söderberg, I., Ljungcrantz, I., Araya, Z., ... & Fredrikson, G. N. (2007). Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in Apobec-1−/−/low-density lipoprotein receptor−/− mice. Journal of the American College of Cardiology, 50(24), 2313-2318.

Figure 3 Macrophage and ABCA-1 Immunoreactivity Colocalize in Aortic Arch Plaques.

Mice treated with the 2D03 antibody at 29 weeks of age.

Schiopu, A., Frendéus, B., Jansson, B., Söderberg, I., Ljungcrantz, I., Araya, Z., ... & Fredrikson, G. N. (2007). Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in Apobec-1−/−/low-density lipoprotein receptor−/− mice. Journal of the American College of Cardiology, 50(24), 2313-2318.

Figure 4 MDA–apoB-100 Peptides Block oxLDL-Induced Monocyte MCP-1 Production In Vitro.

MCP-1 messenger ribonucleic acid (mRNA) relative to 18S mRNA levels in human monocytes incubated with 60
g/ml 2D03, IEI-E3, or FITC-8 in the presence of oxLDL-containing human serum.

Schiopu, A., Frendéus, B., Jansson, B., Söderberg, I., Ljungcrantz, I., Araya, Z., ... & Fredrikson, G. N. (2007). Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in Apobec-1−/−/low-density lipoprotein receptor−/− mice. Journal of the American College of Cardiology, 50(24), 2313-2318.