Mouse Anti-oxLDL (clone 2DO3) scFv-Fc Chimera (CAT#: VS-0425-FY163)
This antibody targets oxidized low-density lipoprotein (oxLDL), a key factor in the development of atherosclerosis. By binding to oxLDL, this scFv-FC could potentially be used for diagnostic imaging or therapeutic intervention in cardiovascular diseases.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Immunogen
- It directed against oxidized peptides derived from human ApoB-100.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human oxLDL
- Species Reactivity
- Human
- Clone
- 2DO3
- Applications
- ELISA
- Related Disease
- Coronary artery disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- In the ELISA assays described in the document, samples were diluted to 0.5 mg/mL.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- oxidized Low-Density Lipoprotein; oxLDL
- Long Name
- oxidized Low-Density Lipoprotein
- Function
- Oxidized low-density lipoprotein (oxLDL) is formed when LDL, the primary carrier of cholesterol in the bloodstream, undergoes oxidation. This process significantly alters the structure and function of LDL, transforming it from a relatively benign molecule into a pro-inflammatory and pro-atherogenic entity.
OxLDL plays a critical role in the development and progression of atherosclerosis. It is readily taken up by macrophages via scavenger receptors, leading to the formation of foam cells, a hallmark of early atherosclerotic lesions. Furthermore, oxLDL can induce endothelial dysfunction, promote the expression of adhesion molecules, stimulate the release of pro-inflammatory cytokines and chemokines, and contribute to the instability of atherosclerotic plaques. Its presence and levels are considered important indicators of cardiovascular risk.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Autoantibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1218-sdAb | Recombinant Anti-Human oxLDL VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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