Mouse Anti-oxLDL (clone 2DO3) scFv-Fc Chimera
CAT#: VS-0425-FY163
This antibody targets oxidized low-density lipoprotein (oxLDL), a key factor in the development of atherosclerosis. By binding to oxLDL, this scFv-FC could potentially be used for diagnostic imaging or therapeutic intervention in cardiovascular diseases.
Specifications
- Immunogen
- It directed against oxidized peptides derived from human ApoB-100.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Antibody Isotype
- scFv-Fc
- Specificity
- Human oxLDL
- Species Reactivity
- Human
- Clone
- 2DO3
- Applications
- ELISA
- Related Disease
- Coronary artery disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- In the ELISA assays described in the document, samples were diluted to 0.5 mg/mL.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- oxidized Low-Density Lipoprotein; oxLDL
- Long Name
- oxidized Low-Density Lipoprotein
- Function
- Oxidized low-density lipoprotein (oxLDL) is formed when LDL, the primary carrier of cholesterol in the bloodstream, undergoes oxidation. This process significantly alters the structure and function of LDL, transforming it from a relatively benign molecule into a pro-inflammatory and pro-atherogenic entity.
OxLDL plays a critical role in the development and progression of atherosclerosis. It is readily taken up by macrophages via scavenger receptors, leading to the formation of foam cells, a hallmark of early atherosclerotic lesions. Furthermore, oxLDL can induce endothelial dysfunction, promote the expression of adhesion molecules, stimulate the release of pro-inflammatory cytokines and chemokines, and contribute to the instability of atherosclerotic plaques. Its presence and levels are considered important indicators of cardiovascular risk.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 2DO3"
- CAT
- Product Name
See other products for "oxLDL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1218-sdAb | Recombinant Anti-Human oxLDL VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0904CL | Anti-Human oxLDL Recombinant Antibody (2-DO3) | IHC, FuncS, FC, Block | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0905CL | Anti-Human oxLDL Recombinant Antibody (Plaque 15) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0906CL | Mouse Anti-oxLDL Recombinant Antibody (TAB-0906CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0907CL | Mouse Anti-oxLDL Recombinant Antibody (TAB-0907CL) | IHC, FuncS, RIA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0908CL | Mouse Anti-oxLDL Recombinant Antibody (TAB-0908CL) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0904CL-S(P) | Anti-Human oxLDL Recombinant Antibody scFv Fragment (2-DO3) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0905CL-S(P) | Anti-Human oxLDL Recombinant Antibody scFv Fragment (Plaque 15) | SDS-PAGE | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0906CL-S(P) | Mouse Anti-oxLDL Recombinant Antibody; scFv Fragment (TAB-0906CL-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0907CL-S(P) | Mouse Anti-oxLDL Recombinant Antibody; scFv Fragment (TAB-0907CL-S(P)) | Competitive RIA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0904CL-F(E) | Anti-Human oxLDL Recombinant Antibody Fab Fragment (2-DO3) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0233YC | Human Anti-oxLDL Recombinant Antibody (clone P2-8) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0234YC | Human Anti-oxLDL Recombinant Antibody (clone P3-175) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0233-YC-S(P) | Human Anti-oxLDL Recombinant Antibody (clone P2-8); scFv Fragment | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0234-YC-S(P) | Human Anti-oxLDL Recombinant Antibody (clone P3-175); scFv Fragment | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0233-YC-F(E) | Human Anti-oxLDL Recombinant Antibody (clone P2-8); Fab Fragment | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0234-YC-F(E) | Human Anti-oxLDL Recombinant Antibody (clone P3-175); Fab Fragment | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2001-FY | Human Anti-OxLDL Recombinant Antibody (clone FY-018) | ELISA | Human IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2001-FY-F(E) | Human Anti-OxLDL Recombinant Antibody (clone FY-018); Fab Fragment | ELISA | Human Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2001-FY-S(P) | Human Anti-OxLDL Recombinant Antibody (clone FY-018); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1124-YJ46 | Human Anti-oxLDL Recombinant Autoantibody (clone P3-116) | ELISA | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1124-YJ47 | Human Anti-oxLDL Recombinant Autoantibody (clone P2-114) | ELISA | Human IgG1 lambda |
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