Anti-LeY (cBR96)-hydrazone-doxorubicin ADC (CAT#: ADC-142LCT)

This ADC product is composed of an anti-Lewis Y (LeY) antibody (clone BR96) conjuagated via a hydrazone linker to doxorubicin (BR96-doxorubicin). It has demonstrated a response in breast, gastrointestinal (GI), lung, cervix, ovary and melanoma treatment by a MOA (Mechanism of Action) of Inhibit Topoisomerase I and cause DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Murine IgG3 Anti-Lewis Y Antibody
  • Clone
  • BR96
  • Antibody Isotype
  • IgG3
  • Linker
  • hydrazone
  • Linker Class/Description
  • Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3-7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0-6.5) and lysosomal (pH 4.5-5.0) compartments of the cell.
  • Drug
  • doxorubicin
  • Drug Class/Description
  • Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

Target

  • Introduction
  • The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase;

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Immunotoxin

CAT Product Name Application Type
AGTO-L017E anti-FUT3 immunotoxin BR96 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L017R anti-FUT3 immunotoxin BR96 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L055E anti-FUT3 immunotoxin BR96 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L055R anti-FUT3 immunotoxin BR96 (scFv)-RTA Cytotoxicity assay, Functional assay

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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