Anti-LeY (cBR96)-hydrazone-doxorubicin ADC (CAT#: ADC-142LCT)

• Antibody Overview
• Murine IgG3 Anti-Lewis Y Antibody

• Clone
• BR96

• Antibody Isotype
• IgG3

• Linker
• hydrazone

• Linker Class/Description
• Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3-7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0-6.5) and lysosomal (pH 4.5-5.0) compartments of the cell.

• Drug
• doxorubicin

• Drug Class/Description
• Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.

• Introduction
• The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

• Alternative Names
• FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase;

• Gene ID
• 2525

• UniProt ID
• A8K737

• AGTO-L017E
• anti-FUT3 immunotoxin BR96 (IgG)-PE

• AGTO-L017R
• anti-FUT3 immunotoxin BR96 (IgG)-RTA

• AGTO-L055E
• anti-FUT3 immunotoxin BR96 (scFv)-PE

• AGTO-L055R
• anti-FUT3 immunotoxin BR96 (scFv)-RTA

• ADC-172LZY
• Anti-Ley (clone BR96)-mc-vc-PABC-MMAF ADC

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