Anti-Ley (clone BR96)-mc-vc-PABC-MMAF ADC
CAT#: ADC-172LZY
This ADC product is composed of an anti-Ley antibody (clone BR96) conjugated via mc-vc-PABC linker to MMAF (BR96-mc-vc-PABC-MMAF). It has demonstrated a response in epithelial tumors treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Normal Tissue
Figure 1 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46966/114457_A_6_6.jpg
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Specifications
- Antibody Overview
- Chimeric (Mouse/Human) monoclonal IgG1, BR96
- Clone
- BR96
- Antibody Isotype
- IgG1
- Linker
- mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAF (monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase;
- Gene ID
- 2525
- UniProt ID
- A8K737
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone BR96"
- CAT
- Product Name
See other products for "FUT3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1628z | Mouse Anti-FUT3 Recombinant Antibody (clone 5H6) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-0258CT | Recombinant Mouse anti-Human FUT3 Monoclonal antibody (3-36MF) | ELISA, ICC, IF, IHC-P, WB | |
| FAMAB-1370CQ | Human Anti-FUT3 Recombinant Antibody (clone PR 5C5) | ELISA, IF, IHC | Human IgG1 |
| VS2-QX87 | Mouse Anti-FUT3 Recombinant Antibody (clone MAL A) | Haemagglutination | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L017E | anti-FUT3 immunotoxin BR96 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L017R | anti-FUT3 immunotoxin BR96 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L055E | anti-FUT3 immunotoxin BR96 (scFv)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L055R | anti-FUT3 immunotoxin BR96 (scFv)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS2-QX25 | Mouse Anti-FUT3 Recombinant Antibody (clone BRIC 87) | ICC, IF, WB | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC703 | Recombinant Anti-FUT3 Vesicular Antibody, EV Displayed (VS-0425-YC703) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2673 | Anti-FUT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2674 | Anti-Human FUT3 Immunohistochemistry Kit | IHC |
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