Anti-Ley (clone BR96)-mc-vc-PABC-MMAF ADC (CAT#: ADC-172LZY)

This ADC product is composed of an anti-Ley antibody (clone BR96) conjugated via mc-vc-PABC linker to MMAF (BR96-mc-vc-PABC-MMAF). It has demonstrated a response in epithelial tumors treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Chimeric (Mouse/Human) monoclonal IgG1, BR96
  • Clone
  • BR96
  • Antibody Isotype
  • IgG1
  • Linker
  • mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAF (monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • FUT3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); LE; Les; FT3B; CD174; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; fucosyltransferase III; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase;

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Immunotoxin

CAT Product Name Application Type
AGTO-L017E anti-FUT3 immunotoxin BR96 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L017R anti-FUT3 immunotoxin BR96 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L055E anti-FUT3 immunotoxin BR96 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L055R anti-FUT3 immunotoxin BR96 (scFv)-RTA Cytotoxicity assay, Functional assay

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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