BV421-A*02:01/Human CALR (MLLSVPLLLG) MHC Tetramer
CAT#: MHC-LC1045
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of CALR-derived peptide of MLLSVPLLLG covering 1-10 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19952/ihc_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to Endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79775/1900_C3_3_blue_red_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2242/8396_B_7_5.jpg
Normal Tissue
Figure 4 Thyroid gland
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2242/8396_B_1_5.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000179218-CALR
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- CALR
- Antigen Species
- Human
- Peptide
- MLLSVPLLLG
- Range
- 1-10
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
- Alternative Names
- CALR; calreticulin; RO; CRT; SSA; cC1qR; HEL-S-99n
- Gene ID
- 811
- UniProt ID
- P27797
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Datasheet
MSDS
COA
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See other products for "CALR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0076MZ | Chicken Anti-Calreticulin Polyclonal IgY | IHC | Chicken antibody |
| BRD-0772MZ | Chicken Anti-Calreticulin Polyclonal IgY | Blocking Assay (BLOCK), IHC (Paraffin) (IHC (P)), ICC (ICC), Flow Cytometry (Flow), IHC (IHC) | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1043 | PE-A*02:01/Human CALR (MLLSVPLLLG) MHC Tetramer | FCM | |
| MHC-LC1044 | APC-A*02:01/Human CALR (MLLSVPLLLG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0443 | Hi-Affi™ Rabbit Anti-CALR Recombinant Antibody (clone DS443AB) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0271-YC | Mouse Anti-CALR Recombinant Antibody (clone 8B2-H6-10.7) | FC, WB | Mouse IgG2a, κ |
| HPAB-0446-YJ | Mouse Anti-CALR Recombinant Antibody (clone FMMU-CRT-10) | FC, WB, CLEIA, ELISA, IHC | Mouse IgG1, κ |
| HPAB-0447-YJ | Human Anti-CALR Recombinant Antibody (clone chFMMU-CRT-10) | ELISA, WB, IHC, FC | Chimeric (mouse/human) IgG1, κ |
| FAMAB-1025CQ | Mouse Anti-CALR Recombinant Antibody (clone SAIC-16D-6B9) | WB, Immuno-MRM, ELISA | Mouse IgG1 |
| VS3-CJ840 | Rabbit Anti-CALR Recombinant Antibody (VS3-CJ840) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0271-YC-S(P) | Mouse Anti-CALR Recombinant Antibody (clone 8B2-H6-10.7); scFv Fragment | FC, WB | Mouse scFv |
| HPAB-0446-YJ-S(P) | Mouse Anti-CALR Recombinant Antibody (clone FMMU-CRT-10); scFv Fragment | ELISA, WB, IHC, FC | Mouse scFv |
| HPAB-0447-YJ-S(P) | Mouse Anti-CALR Recombinant Antibody (clone chFMMU-CRT-10); scFv Fragment | ELISA, WB, IHC, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0271-YC-F(E) | Mouse Anti-CALR Recombinant Antibody (clone 8B2-H6-10.7); Fab Fragment | FC, WB | Mouse Fab |
| HPAB-0446-YJ-F(E) | Mouse Anti-CALR Recombinant Antibody (clone FMMU-CRT-10); Fab Fragment | ELISA, WB, IHC, FC | Mouse Fab |
| HPAB-0447-YJ-F(E) | Human Anti-CALR Recombinant Antibody (clone chFMMU-CRT-10); Fab Fragment | ELISA, WB, IHC, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC841 | AbPlus™ Anti-CALR Magnetic Beads (VS-0724-YC841) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY61 | Mouse Anti-NHP CALR Recombinant Antibody (clone FMC 75) | WB, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY297 | Anti-CALR Immunohistochemistry Kit | IHC | |
| VS-0525-XY946 | Anti-Mouse CALR Immunohistochemistry Kit | IHC | |
| VS-0525-XY947 | Anti-Human CALR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC114 | CytoStream™ Rabbit Anti-CALR Recombinant Antibody (VS13-YC114) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
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