Anti-M1S1 (clone C16)-vc-PABC-Aur0101 ADC (CAT#: ADC-121LZY)

• Antibody Overview
• Anti-M1S1 mAb, C16

• Clone
• C16

• Antibody Conjugation
• A glutamine tag was introduced at selected positions of anti-M1S1 C16 antibody through
  residue insertion or substitution using site directed mutagenesis,and the engineered antibody is conjugated toC6-VC-PABC-Aur0101

• Linker
• VC-PABC (valine-citrulline-p-aminobenzylcarbamate)

• Linker Class/Description
• Class: Enzymatically cleavable linker-Peptide linker
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• Aur0101

• Introduction
• This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

• Alternative Names
• TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733;

• Gene ID
• 4070

• UniProt ID
• P09758

• ADC-128LZY
• Anti-M1S1 (clone C16)-vc-MMAD ADC

• ADC-130LZY
• Anti-M1S1 (clone C16)-mc-vc-MMAD ADC

• ADC-095LZY
• Anti-M1S1 (clone C16)-PEG6-MMAD ADC

• ADC-096LZY
• Anti-M1S1 (clone C16)-PEG6-Aur3377 ADC

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