SmartAb™ Recombinant Anti-TACSTD2 pH-dependent Antibody (Clone KM4097)
CAT#: VS-0825-YC320
The anti-TACSTD2 pH-dependent antibody (clone KM4097) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to human TACSTD2. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for TACSTD2 under acidic conditions compared to physiological pH. Using a yeast surface display system with a pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from TACSTD2 at pH 6.0. This pH-sensitive antibody retains its binding affinity on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human TACSTD2, also known as TROP2, is a transmembrane protein that is involved in cell proliferation. It is frequently overexpressed in a variety of cancers and is a promising therapeutic target.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/893_A3_7_blue_red_green.jpg
Normal Tissue
Figure 3 Urinary bladder
Urothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43104/93730_A_6_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
❮
❯
Specifications
- Immunogen
- Pc1 cells
- Host Species
- Mouse
- Type
- Mouse IgG1 kappa
- Specificity
- Human TACSTD2
- Species Reactivity
- Human
- Clone
- KM4097
- Applications
- ELISA, FC, WB
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; tumor-associated calcium signal transducer 2; 40kD glycoprotein, identified by monoclonal antibody GA733; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; epithelial glycoprotein-1; gastrointestinal tumor-associated antigen GA7331; membrane component, chromosome 1, surface marker 1; pancreatic carcinoma marker protein GA733-1; pancreatic carcinoma marker protein GA7331; trophoblast cell surface antigen 2; truncated TACSTD2
- Gene ID
- 4070
- UniProt ID
- P09758
- Long Name
- tumor-associated calcium signal transducer 2
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
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